Dr. Claver-NN only

Answer 2 question, be specific. Based on the case study.

1. What other substances must be transported from the tubular fluid into the PCT cell (across the apical or luminal membrane) or from the PCT cell into the interstitial fluid (across basolateral membrane) as part of the transport of the H+?

2. What would happen to the amount of H+ secreted into the renal tubule if the activity of the H+/ K+ ATPase were increased? Are there diseases or other conditions that might enhance the activity of this sodium H pump?