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20180309211125example_how_to_make_seminar11.pptxAvian Influenza
Abdulrahim Mutair Alamri
201315960
(34)
Supervisor : Prof. Dr. Mamdoh Harahsha
Family : Orthomyxovirus
Morphology : - Helical
- Envelope
Genome: -ssRNA
Replication:
Endocytosis Nucleus Budding
Avian Influenza
Avian influenza (“bird flu”) is an infectious disease of birds caused by type A strains of the influenza virus
Avian influenza viruses do not normally infect humans. However, some are zoonotic, meaning that they can infect humans and cause disease.
Pathogenesis
Droplet RT with symptoms (malaise, cough, sore throat). Secretion .
Complications :
severe respiratory illness (e.g. pneumonia and respiratory failure)
Death may occur.
Transmission
Direct contact with infected poultry
surfaces and objects contaminated
Directly from birds or from avian virus-contaminated environments to people
Prevention and control
Avoid sources of exposure whenever possible.
People who work with poultry : use of personal protective equipment and hand hygiene.
No vaccination
Immunity
- Humoral : not important
- Cellular : TC cells and Macrophage
Avian Influenza Diagnosis
- Clinical Signs
- Virus Isolation and Characterization
- Serology
- PCR
- Histopathology and Immunochemistry
Treatment
Anti viral drugs :
Neuraminidase inhibitors : such as Zanamivir
inhibitors of the viral M2 protein : such as Amantadine.
References
http://en.wikipedia.org/wiki/Avian_influenza
http://www.cdc.gov/flu/avianflu/prevention.htm
http://www.who.int/influenza/human_animal_interface/avian_influenza/en/
HA
PB1
PB2
PA
NP
NA
MA
NS
M2
Hemagglutinin
Neuraminidase
M1
