6 question needed due by 15 hrs

Page 5 of 5/Immunology

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Question 1

1. The picture below depicts the innate immune system recognition of a pathogen by a mouse dendritic cell. Given the PAMPs recoginzed by this cells, match the red boxes with the Pattern Recognition Receptor depicted.

Box A

Box B

Box C

1.

Box D

A. TLR-11 B. TLR-7 C. TLR-1 D. TLR-9 E. TLR-4 F. TLR-3

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Question 2

1. Given the PAMPs highlighted in Question 1, which class of pathogen is depicted as being recognized by the PRRs in the figure

	A.	Virus
	B.	Prion
	C.	Bacteria
	D.	Protozoan Parasite

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Question 3

1. A middle age male suffers from frequent Staph aureus infections that cause severe skin lesions shown in the picture below. Neutrophils from this pateint and a normal patient were treated with a dye that turns blue in the presence of toxic reactive oxygen species (Bottom figures).

Which patient sample is from the male with recurrentskin infections (enter A or B)? Blank 1

This patient likely has a genetic defect in which gene? Blank 2

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Question 4

1. There are many examples where our immune system "over responds" to pathogen insult and causes severe damage or death. An example is seen below where mice injected with a lethal dose of Gram negative O18 E coli will die within 5 days from multiple organ failure. In contrast, mice in which one of the Pattern Recognition Receptors is deleted/knocked out (PRRX) are actually protected from the lethal dose of E coli (Note: The PRRx and SAM KO lines overlay in the right graph and are 100% across the entire time period.. A deletion of the TLR2 is shown as a control. In addition, a deletion of a signaling adaptor molecule also protects the mice from the lethal dose of E coli. Given the information in the experiment below, what are the identities of PRRX and SAM?

PRR X Blank 1

SAM Blank 2

The pathology shown in the experiment below is called Blank 3?

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Question 5

1. The diagram below depicts a cell-type that is particularly adept at recognizing a single class of pathogen (i.e. bacterium, virus, fungi, or helminth) due to high levels of the PRRs shown. It aids in clearance of infection by producing very high levels of Type I interferons compared to most other cell types.

These cell types are called Blank 1 cells?

Effective in immune response to this class of pathogen Blank 2?

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Question 6

1. I was using a Google Image search to find pictures that do a good job illustrating how Pattern Recognition Receptors work when I found the figure below at a biotech companies website. I really like his figure and it does a great job conveying how TLR recognize PAMPs and signal to activate proinflammatory genes. Unfortunately, there is at least one major error in this figure that indicates that the illustrator did not completely understand the immunology of PRRs. What is the mistake in this figure? If this figure were correct, which class of pathogens might escape recognition by PRRs (Limit 3-4 sentences)?