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Authors:

Li, D., Xing, C., Li, Y., & Zhu, X.

Journal: Journal of Stroke and Cerebrovascular Diseases, 

Link: https://www-sciencedirect-com.lopes.idm.oclc.org/science/article/pii/S1052305720304092?via%3Dihub

Authors: Abidi, M. Z., Hari, P., Chen, M., Kim, S., Battiwala, M., Dahi, P. B., ... & Green, J.

Journal: Bone marrow transplantation,

The link: https://sci-hub.st/https://www.nature.com/articles/s41409-019-0457-9

Author:

Wang, R., He, M., Ou, X., Xie, X., & Kang, Y. Journal: Clinical Neurology and Neurosurgery

Link: https://www-sciencedirect-com.lopes.idm.oclc.org/science/article/pii/S0303846720303942?via%3Dihub

Author:

Wu, Y., Zhou, L., Yao, M., Zhu, Y., Ni, J., Cui, L., & Peng, B.

Journal: Journal of the Neurological Sciences

Link: https://linkinghub-elsevier-com.lopes.idm.oclc.org/retrieve/pii/S0022510X20303543

Author: Sokolova, A., & Smith, S. D. Journal: Australasian Journal of Dermatology, 

Link: https://sci-hub.st/https://onlinelibrary.wiley.com/doi/abs/10.1111/ajd.12331

Author:Xu, M., Xu, L., Du, H., Shan, W., Feng, J., Zhai, G., & Yang, X.

Journal: Neuropsychiatric Disease and Treatment

Link: https://search-proquest-com.lopes.idm.oclc.org/docview/2414110506?accountid=7374

Article Title and Year Published

Title: Elevated plasma fibrinogen indicates short-term poor outcomes in patients with acute ischemic stroke after intravenous thrombolysis. 

Year of publication: 2020

Article Title: Virus detection in the cerebrospinal fluid of hematopoietic stem cell transplant recipients is associated with poor patient outcomes: a CIBMTR contemporary longitudinal study. Bone marrow transplantation

Year: 2019

Article title: CRP Albumin ratio is positively associated with poor outcome in patients with traumatic brain injury. 

Year Published:2020

Article Title:

Elevated fasting blood glucose is predictive of the severity and poor outcome in nondiabetic patients with cerebral venous thrombosis

Year Published: 2020

Article title: Factors contributing to poor treatment outcomes in childhood atopic dermatitis. 

Year Published: 2015

Article Title: Decreased Serum Retinoic Acid May Predict Poor Outcome in Ischemic Stroke Patients.

Year Published: 2020

Research Questions (Qualitative)/Hypothesis (Quantitative), and Purposes/Aim of Study

Research hypothesis: Elevated plasma fibrinogen showcases brief, the poor outcome in patients diagnosed with acute ischemic stroke immediately they have undergone an intravenous thrombolysis

Research objective:

To establish whether elevated plasma fibrinogen showcases poor patient outcome in the short-term in individuals diagnosed with acute ischemic stroke after undergoing intravenous thrombolysis

The research hypothesis: Allogeneic hematopoietic cell transplant is a curative treatment choice for an extensive range of disorders.

The main objective is to showcase that virus detection in the hematopoietic cell’s cerebrospinal fluid in transplant recipients is related to poor outcomes in patients

The research hypothesis: CRM Albumin ratio in individuals diagnosed with traumatic brain injury is positively associated with poor outcome

The research objective: To determine whether the CRB Albumin ratio in people suffering from a traumatic brain injury is associated with poor outcome.

The research hypothesis: Elevated fasting blood glucose if forecasting of the poor outcome and severity in cerebral venous thrombosis patients who are nondiabetic.

Research Objective: To establish the association between FBG and outcome and severity CVT.

The research question: what are some of the factors that contribute to poor-management of post-operative abdominal pain in patients

Research Objective: To establish factors contributing to poor-management of post-operative abdominal pain in patients.

The research hypothesis: reduced Serum retinoic Acid may predict Poor Outcomes in individuals diagnosed with ischemic stroke.

The research objective: The research purpose of investigate the association between 3-month functional outcome and serum RA after ischemic stroke.

Design (Quantitative, Qualitative, or other)

The research design is a retrospective cohort research

The study took the form of quantitative research, where data was collected from the CIBMTR working group.

The research was a retrospective cohort study

The preferred study design was quantitative because of its ability to collect a large amount of data.

A quantitative research design was adopted to help in realizing the objectives of this study.

The research took the form of a retrospective cohort study

Setting/Sample

The research encompassed 176 ischemic patients

An electronic database search was done to identify research works over 500 transplant centers around the globe.

The sample included 181 patients diagnosed with TBI

CVT patients at Peking Union Medical College Hospital between January 2009 and December 2019 were used.

The research relied on five databases. They Include; Synergy, Blackwell, Ovid, Pub-Medline, and Google scholar were used.

Ischemic stroke patients were prospectively recruited between January 2019 and December 2019 within 24 hours after being diagnosed with a stroke.

Methods: Intervention/Instruments

The research conducted a retrospective exploration of 176 respondents diagnosed with ischemic stroke and had received intravenous thrombolysis. The respondents had also been exposed to a recombinant tissue plasminogen activator. They were also subjected to plasma fibrinogen within a day after the onset of stroke.

HCT data was collected from CMBTR working group transplant centers around the globe.

The research retrospected TBI patients and gathered laboratory and clinical data 151

Data collection was done at baseline, including aspects of clinical presentations, mode of onset, Glasgow Coma Scale Score, intracranial pressure, and NIHSS.

The research methodology was literature-based and involved the use of keywords such as post-operative pain, abdominal pain, painkillers, analgesia, and pain intensity.

After admission, clinical data, demographic attributes, and medical history of the patients were collected. The severity of stroke was evaluated using the NIHS scale. Its etiology was categorized based on the TOAST trial.

Analysis

The data in the research were expressed as either median or standard deviations means. Data in categories were expressed as percentages and frequencies.

Transplant factors, patients, and disease were statistically reported as medians or frequencies as appropriate.

Multivariate and univariate logistic regression was done to establish independent morality risk factor

Continuous variables were computed as Standard deviation means. Moreover, Abnormal variables were expressed using medians, whereas continuous variables were evaluated using the Mann-Whitney U-test and the student t-test.

The searches were screened to obtain relevant themes for the study. The relevant articles had full-text versions obtained.

Data analysis was carried out using the SPSS tool.

Key Findings

57.4 percent of the patients realized excellent outcomes, 42.6 percent had poor outcomes, whereas about 14 patients lost there lives out of the 176 ischemic patients assessed within two weeks.

HHV-6 is a dominant CNS-V. HHV-6 CNS-V happens during the initial stages of the transplant, and the individuals exposed to CBT are predominant.

54 patients had a 35.8% mortality rate and poor survival outcome

FBG at admission is associated with CVT severity in nondiabetic patients. Moreover, an elevated FBG is an independent forecaster of the poor outcome when patients are discharged

Despite several improvements in anesthesia, analgesia, and delivery techniques, post-operative pain management remains suboptimal in adult patients.

43.3 percent of the participants realized poor outcomes and were more likely relative to those who did not experience poor outcomes of possessing higher systolic blood pressure.

Recommendations

The present research showcases that high plasma fibrinogen levels in patients are correlated with a patient’s poor outcome within two weeks for individuals receiving intravenous rt-PA after AIS.

There is a need to conduct further studies better explain the clinical outcomes and incidence of non-HHV-6 and HHV-6 associated viral encephalitis.

There is a need for multiple and additional prospective research with vast sample sizes to assess the forecasting value of CAR in TBI patients

There is a need to conduct future research to assess if glucose control can leverage CVT outcomes

Analgesia should be employed by the clock and in a multimodal fashion based on the needs and requirements of the patient.

Explanation of How the Article Supports Your Identified Barrier or Issue in Health Care

The study showcases that extreme levels of plasma fibrinogen level in less than a day after stroke onset is highly associated with poor outcome in the short-run after the culmination of 14 days in Individuals diagnosed with AIS and exposed to intravenous thrombolysis. Curbing the dangers of poor outcomes remains a challenge in people with high fibrinogen after intravenous thrombolysis is still a challenge. The research is essential since it showcases that there is a need for large prospective research woks to ensure that there is better characterization of underlying factors and techniques to curb this effect.

The findings of this research function improve physician’s comprehension of the mortality effect of HHV-6 CNS-V and HHV-6 after an immediate HCT. Moreover, HCT patients are highly vulnerable to infections and a high mortality rate. As such, this article ensures that any clinical centers or transplant units need to adhere to protocol and report any consecutive transplants and report follow-ups.

CAR is classified as an independent element of mortality in TBI patients. Encompassing CAR into a productive framework average the value in forecasting the TBP patients’ outcome. The article is vital since it showcases how poor outcome in TBI patients could be eliminated

He article showcases that FBG at admission is correlated with increased CVT severity. It also showcases FBG as an independent predictor of poor outcomes when the patient is discharged. As such, this article is crucial in validating if glucose control can play a crucial role in leveraging CVT outcomes.

The article suggests that in general, there is a need for leveraging management of pain in post-operative adults to enhance their safety, recovery, and curb morbidity. As such, issues of the poor patient outcome can be avoided with relevant education coupled with robust guidelines and policies backed by up to date evidence.

The article showcases that low RA serum levels at the acute stage are linked with a brief prognosis among IS patients. The article indicates that RA may be used in a clinical setting as a potential prognostic biomarker for IS. the article recommends that there is a need for further research using samples from other populations of UIS to validate the findings. Furthermore, the article is essential because it shows that therapeutic considerations and potential pathophysiological mechanisms may still be determinants of poor patient outcomes i.