week four discussion mha 610

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albn10

2015-02-22 17:31

can you answer this question?

In this discussion, we will investigate confidence intervals and t tests for continuous data. To do this, we will revisit the TAA data that you studied in the Week Three assignment.

You may recall from the Week Three assignment that you have available data on 12 tumor-associated antigens (TAAs), from 90 normal individuals (controls) and 160 hepatocellular carcinoma patients (cases). These data are in the Excel file MHA610_Week 3_Assignment_Data.xls; the levels of the 12 TAAs are given in the columns with headings Ab14, HCC1, IMP1, KOC, MDM2, NPM1, P16, P53, P90, RaIA, and Survivin.

    • First, randomly select three of the 12 TAAs for further study. 

 

    • Next, Perform two sample t-tests for comparing the levels of each of your three TAAs between the cases and the controls. 

 

    • Then, Use the t-tests to order the TAAs in terms of relative ability to discriminate between the cases and controls, from best to worst discriminator. Is this ordering helpful if you want to select a subset of TAAs to discriminate between cases and controls?  Assume for now that you can judge the relative merits of your three TAAs by the magnitudes of their respective two-sided p-values from the two sample t-tests, so that your best discriminator is the TAA with the smallest p-value.  

 

  • Lastly, Construct and report 95% confidence intervals for the mean level of your best TAA discriminator in the controls, the mean level of your best TAA discriminator in the cases, and the difference in mean levels (cases - controls). Discuss whether your confidence intervals are concordant with the t-tests.
  • sourcegroupgroupidAb14HCC1IMP1KOCMDM2NPM1P16P53P62P90
    SD control00.1020.0680.0830.0230.1170.120.1020.0980.1770.097
    SD control00.020.060.0350.0160.0050.0040.0170.0140.0490.011
    SD control00.0640.130.1110.0580.0920.0460.2580.0570.280.05
    SD control00.0680.0410.0560.0190.0770.050.0670.0550.1040.049
    SD control00.0360.070.0670.040.0260.0190.0570.0270.1070.019
    SD control00.0490.1880.0790.0630.0730.0180.1070.0530.1280.027
    SD control00.0530.2310.2140.1050.050.0090.2770.0610.2530.06
    SD control00.0710.0450.1330.190.08600.0980.0550.1610.058
    SD control00.0660.1390.1050.0650.0950.0410.1930.0750.1880.037
    SD control00.0710.0770.0950.0390.1320.0580.220.0770.1080.064
    SD control00.0330.0910.0640.0590.0120.010.0390.0340.0870.025
    SD control00.0530.0240.060.0260.1470.1020.1140.0640.1080.05
    SD control00.0450.0140.050.020.0450.1440.0510.0390.0490.029
    SD control00.1530.080.0710.0340.0210.1180.0630.0410.0710.029
    SD control00.0330.0230.0470.0190.0480.2190.0560.0430.0710.039
    SD control00.1110.0470.1040.0490.1030.0640.2850.090.1850.452
    SD control00.0820.0230.0710.2580.0910.1290.1160.0550.1650.11
    SD control00.1150.010.3830.1620.1130.2290.2980.0750.3470.082
    SD control00.0540.0270.3270.0260.0350.0670.3890.2240.1210.047
    SD control00.0480.1230.1190.060.0430.0360.1180.0850.1490.031
    SD control00.10.0550.0580.0260.1450.1190.3970.0870.20.083
    SD control00.0790.070.1440.0710.1590.1440.2530.080.1950.116
    SD control00.0990.0090.1040.1020.0290.0990.6850.0790.1130.056
    SD control00.0840.0260.0870.0320.0930.0660.1180.0690.2130.079
    SD control00.0270.0580.0850.050.0380.0270.0480.0280.1280.019
    SD control00.0710.0860.0650.0460.0270.230.0870.060.0530.024
    SD control00.0270.0680.1810.0480.0270.0050.0560.0270.1570.013
    SD control00.1080.0490.1530.0570.0860.0550.130.050.1870.042
    SD control00.0550.1180.0630.0480.0230.0250.0470.0310.0680.037
    SD control00.0840.0680.0550.0230.1210.130.1080.0730.1530.064
    SD control00.1320.0230.10.0580.2170.0540.2070.0770.3040.127
    SD control00.0770.0570.0310.0160.0520.070.0770.060.0590.055
    SD control00.0820.0480.0440.0220.0740.3080.1790.0510.0910.065
    SD control00.0440.0550.1870.0790.0760.0160.1020.0590.1480.039
    SD control00.0540.0580.0450.0210.0110.1010.4680.0850.0520.029
    SD control00.0350.0340.1320.0750.0410.0080.0760.0460.1190.029
    SD control00.10.0230.1070.0640.0480.0290.1210.0310.0890.028
    SD control00.0630.020.0810.0970.0830.0480.0440.0250.0470.033
    SD control00.0940.0260.2510.2710.1240.2760.2320.0670.1730.057
    SD control00.1450.0680.160.0290.1590.4460.2780.1290.1960.108
    SD control00.0510.1110.1540.1110.1090.0870.1510.0910.1430.054
    SD control00.0750.1310.0870.0590.0380.0550.1530.0970.0640.039
    SD control00.0610.020.0920.0680.0580.1520.2750.0580.1490.077
    SD control00.0350.0740.0890.040.1250.0430.0650.0750.1230.058
    SD control00.0380.0450.0830.0490.0570.0730.0910.0670.1170.038
    SD control00.050.0420.1890.060.0780.0360.1710.0330.2550.041
    SD control00.0810.2360.2690.10.0710.0780.320.0540.2270.075
    SD control00.0510.0260.0760.0640.0210.0180.0910.070.0750.047
    SD control00.0650.0270.1280.080.0740.0290.1540.0470.1360.038
    SD control00.0360.0320.0240.0130.0210.0430.0210.0150.0190.02
    SD control00.1030.0160.0540.0260.1150.6160.0820.080.0890.06
    SD control00.0960.020.0860.0270.1670.1030.1330.0720.080.066
    SD control00.1170.0450.1680.2560.1460.4050.20.0240.1330.117
    SD control00.0370.1270.1850.0720.0660.0550.150.0390.0910.029
    SD control00.0710.0360.080.0250.0970.20.1410.0550.1750.06
    SD control00.0710.0410.050.0330.0870.0290.1340.0660.1030.065
    SD control00.0520.0880.1140.0350.0890.0390.0840.0650.0770.048
    SD control00.0490.0390.2060.0980.1250.0580.1840.0550.1560.059
    SD control00.0610.0210.0260.0160.0520.3550.0820.0350.0320.019
    SD control00.0430.0420.0850.0520.0530.2710.0960.0450.080.039
    SD control00.0450.0770.2030.1070.0650.0070.0580.0590.1230.026
    SD control00.260.0860.1410.0240.1810.5290.2540.1260.220.098
    SD control00.0250.0130.0590.050.0360.0580.1920.0290.0430.031
    SD control00.0290.0040.0980.0350.0250.0530.0680.0180.0230.016
    SD control00.0640.0480.1320.090.0820.190.1510.0420.1610.038
    SD control00.0480.0360.0530.0550.090.0460.0890.0590.0570.029
    SD control00.0370.0140.0920.1560.0470.0420.1160.0270.0480.034
    SD control00.0360.0580.0820.0520.0770.0340.1360.0610.0810.031
    SD control00.0570.0340.10.0310.0920.1420.1930.0830.0560.07
    SD control00.060.0440.1360.0340.1130.0730.1120.0660.2390.043
    SD control00.0630.0630.1350.0520.0710.0560.1050.0430.0750.024
    SD control00.0560.0770.0660.0350.0570.0390.0930.0460.0760.04
    SD control00.0440.030.160.0760.0690.0420.1320.0740.080.037
    SD control00.0470.0260.0640.0230.0560.0370.0210.0270.0760.02
    SD control00.0320.0140.0830.060.0870.0360.0770.0280.0480.033
    SD control00.0810.040.070.0410.0370.070.0860.0410.0360.04
    SD control00.1140.1480.3420.1210.1130.1610.310.0710.1720.05
    SD control00.0260.0360.0640.0260.0410.0520.0520.0450.0150.022
    SD control00.0820.0310.0920.020.0850.210.1990.0350.1030.062
    SD control00.0120.0230.0920.0230.070.0040.0660.0260.0570.021
    SD control00.0680.0370.060.020.0940.0190.0850.0780.0890.029
    SD control00.0570.010.1850.0420.1570.0590.1690.0740.2480.053
    SD control00.0350.0450.0770.0280.0590.0540.0630.0340.1310.028
    SD control00.0510.0220.040.0180.0830.1050.0510.0450.0490.043
    SD control00.0720.0120.0750.0120.0990.0490.0350.0540.0880.072
    SD control00.1840.0680.1290.0230.1260.0590.080.0930.1680.069
    SD control00.0330.0180.1070.0650.0920.0210.0730.0430.0960.04
    SD control00.0830.0520.1430.0430.0990.0760.1160.0670.0930.051
    SD control00.0360.0180.0920.020.0310.0380.0530.0490.0430.029
    SD control00.0840.0340.0320.0140.0130.0640.1070.0850.0330.044
    Koreacase10.1820.0680.0830.0370.170.7290.1950.0570.2290.185
    Koreacase10.0690.070.1260.0360.1250.3360.0920.0480.1920.088
    Koreacase10.0720.1550.1380.080.1160.3560.1050.1020.2340.095
    Koreacase10.490.1980.1760.1470.1840.2340.3940.0980.4360.307
    Koreacase10.0620.1490.1410.0640.1530.2150.1190.1510.2140.11
    Koreacase10.2350.4770.3040.1720.4680.5040.5490.2720.7760.529
    Koreacase10.1130.1130.0950.0730.2070.5140.1450.1270.2260.154
    Koreacase10.1080.0720.1690.0730.1940.6080.1430.0890.3640.127
    Koreacase10.1190.3440.370.2010.2950.6130.420.3620.2980.143
    Koreacase10.120.0830.0880.0680.1240.1210.1960.1270.3020.228
    Koreacase10.070.1240.1940.0380.070.0980.230.2170.3570.169
    Koreacase10.0690.4050.1430.1020.2610.1260.1350.2760.2840.095
    Koreacase10.1010.0950.2630.040.1270.1340.6760.0910.2950.325
    Koreacase10.0770.1120.2630.0420.080.3080.1070.0870.1830.125
    Koreacase10.0470.130.3160.0890.1570.2060.1150.1940.1950.092
    Koreacase10.4930.1280.4350.5880.1540.8020.4840.1450.4060.33
    Koreacase10.0760.1261.4640.0320.1330.3550.1260.4270.2370.124
    Koreacase10.0880.0770.660.0310.1060.260.1510.070.2340.137
    Koreacase10.0640.0880.0960.0570.0840.120.1010.0830.260.067
    Koreacase10.0630.0450.140.1930.1490.0460.1170.1540.2140.092
    Koreacase10.1970.582.0690.310.4290.2140.3390.3750.5680.255
    Koreacase10.0530.0680.0950.0610.1660.0730.0970.0820.2540.06
    Koreacase10.1820.1820.2230.0680.0650.1180.3050.6160.4390.258
    Koreacase10.0340.1030.1590.0960.0980.1490.1530.2350.2330.102
    Koreacase10.0770.020.0690.0230.1330.1180.1430.190.4180.218
    Koreacase10.0740.1030.1440.0290.1621.5350.0920.1420.2260.142
    Koreacase10.150.0790.2750.1320.2370.4550.1660.1980.350.164
    Koreacase10.1990.1870.1070.0860.1130.1870.4410.0660.3980.277
    Koreacase10.0530.1280.2080.0720.1510.110.1380.2770.2250.152
    Koreacase10.0430.0380.0650.0270.1070.4020.1670.0630.2180.079
    Koreacase10.1060.0970.1210.0640.1630.1180.1770.1380.3990.109
    Koreacase10.090.0990.0510.0430.0770.0780.1570.0650.2340.181
    Koreacase10.0650.1310.140.0930.1810.260.1270.3290.1170.056
    Koreacase10.1370.1170.0860.0620.1420.1730.2840.140.3290.134
    Koreacase10.1650.1420.1980.1190.1531.1030.470.1530.5920.195
    Koreacase10.0730.2920.2080.1150.2620.1580.2120.2090.2670.142
    Koreacase10.0910.0270.1260.0690.140.8420.1320.0630.1970.224
    Koreacase10.0640.0630.1690.0760.0770.0420.1680.1250.1840.045
    Koreacase10.2780.1370.2220.1230.1270.1470.1130.0990.1980.06
    Koreacase10.1740.020.1510.0270.1240.0860.4980.0680.350.185
    Koreacase10.0690.0880.1820.0940.1720.4150.1350.2630.2810.121
    Koreacase10.1380.1170.1940.0920.1881.2450.2130.1890.3970.201
    Koreacase10.0640.0610.1310.1130.1490.2870.2150.0540.290.162
    Koreacase10.1110.0360.090.1350.0960.1510.1460.1230.2010.198
    Koreacase10.0790.140.2750.2140.3630.2920.1560.0620.1490.076
    Koreacase10.070.0360.0540.0670.0450.070.1760.0750.3140.179
    Koreacase10.0870.1510.0950.090.0750.170.2230.0750.2960.18
    Koreacase10.1430.2270.0980.0860.1210.0860.1110.2030.1050.065
    Koreacase10.1170.0180.0660.0220.0740.5760.1720.0410.2310.209
    Koreacase10.0650.1220.1110.0430.1250.1780.2070.060.1550.069
    Koreacase10.0790.1240.1940.0640.1170.0980.1730.150.3020.078
    Koreacase10.4880.1890.3320.120.2570.6261.1660.1540.9070.66
    Koreacase10.0750.180.1930.0730.150.1070.1780.1210.270.099
    Koreacase10.1720.0610.0860.0610.1330.1640.1260.130.230.244
    Koreacase10.070.0590.0860.1090.060.0740.2230.0930.3260.07
    Koreacase10.0560.051.6030.0570.0540.2170.3160.1810.3010.076
    Koreacase10.0820.1080.0820.0570.4010.7640.1010.0760.1520.102
    Koreacase10.0590.0470.070.1120.1260.1070.2990.1190.2420.149
    Koreacase10.0710.0850.1510.3070.1240.490.20.1550.2920.131
    Koreacase10.0350.3820.1520.130.1430.130.1980.2580.1350.059
    Koreacase10.1230.0160.0940.010.090.1040.1270.0630.1980.123
    Koreacase10.0810.1120.1740.0360.1350.1480.2060.1840.2040.117
    Koreacase10.0510.0680.2630.0710.1760.1570.0990.7570.1920.103
    Koreacase10.0930.090.0380.0430.0890.1640.4710.0670.4010.177
    Koreacase10.0380.0540.0850.0360.1170.1910.090.0540.1590.088
    Koreacase10.0910.0360.0950.0580.0940.0380.1940.4330.1920.077
    Koreacase10.1570.0940.1250.0950.0930.0590.1690.1160.2860.13
    Koreacase10.2860.1980.1080.1250.1110.1620.4130.1640.5170.317
    Koreacase10.0690.2520.2720.1580.4820.1790.170.2710.3280.092
    Koreacase10.070.0470.0550.1250.060.5270.2750.0930.3220.074
    Koreacase10.070.1570.10.070.070.0610.2820.1360.4010.13
    Koreacase10.0290.3740.1760.1280.2050.1480.1850.1790.1810.032
    Koreacase10.0470.0110.040.0030.0760.0680.1180.2970.180.068
    Koreacase10.0740.0410.1220.0280.0660.0520.2560.0790.2270.129
    Koreacase10.0570.1120.1050.0840.140.130.2590.1240.3060.112
    Koreacase10.3520.1130.0740.0620.1290.1480.730.1230.6630.451
    Koreacase10.0640.2520.1690.090.1610.4960.1550.1140.2010.138
    Koreacase10.1320.1580.3780.0830.1970.410.3730.180.3720.28
    Koreacase10.0770.0950.0540.0670.1550.0880.1960.110.3410.213
    Koreacase10.110.0430.0750.0670.1010.5160.2490.0980.2530.129
    Koreacase10.0540.3470.2170.1780.4460.2840.1780.2440.2150.104
    Koreacase10.2970.0540.0870.090.080.1040.180.1010.2590.133
    Koreacase10.0830.2250.1640.2450.1270.0540.2350.1280.2010.184
    Koreacase10.1290.2990.1620.110.2750.0560.1770.1980.960.105
    Chinacase10.0260.0090.0480.0380.0720.1450.2540.0770.1560.109
    Chinacase10.0480.0644.0310.1120.1520.5130.3850.1013.3470.224
    Chinacase10.1520.0730.2280.2480.0450.2590.220.0380.0550.269
    Chinacase10.06200.0290.0080.090.0210.0490.00100.02
    Chinacase10.1560.2120.1720.0510.2110.3220.40.1080.3120.129
    Chinacase10.0580.0230.1340.0550.1490.1110.5240.1090.2290.259
    Chinacase10.090.0880.1580.0730.070.0690.6970.0530.4680.24
    Chinacase10.0340.0630.0740.0750.1020.3470.2150.1240.1220.085
    Chinacase10.0860.0230.1750.020.1090.2480.0590.0280.4030.085
    Chinacase10.020.110.110.2550.0960.2060.9410.0980.1690.175
    Chinacase10.110.1440.1822.1930.0460.1370.3660.060.270.165
    Chinacase10.1620.2680.180.0390.0820.1060.2990.0620.4470.109
    Chinacase10.05200.0540.0770.0430.0280.1480.0810.190.059
    Chinacase10.0820.0290.3140.040.0910.4830.0892.2231.560.182
    Chinacase10.0820.0850.060.0140.0620.160.0640.02100.09
    Chinacase10.1260.0460.1360.2120.1490.6020.2740.5020.2050.164
    Chinacase10.1180.0961.5350.2050.0720.0780.2220.1070.070.133
    Chinacase10.1760.0960.1450.1390.1340.2190.2150.1140.0810.153
    Chinacase10.160.4470.2230.7070.1650.190.3290.1910.3090.074
    Chinacase10.080.080.0980.1070.0270.2330.2620.120.1270.097
    Chinacase10.1040.3040.3980.1760.6020.4240.60.060.6970.174
    Chinacase10.0140.0870.7710.0960.2210.1190.2520.1220.2370.081
    Chinacase100.0470.1350.0550.0750.0960.0540.0430.0990.034
    Chinacase10.280.3320.2170.1110.090.2230.4030.0620.7640.089
    Chinacase10.1080.0110.0630.1780.1260.1670.1750.1040.1510.148
    Chinacase10.120.040.1160.0340.0560.3380.0820.1530.2030.176
    Chinacase10.0720.0950.0880.0270.1340.4820.0990.0550.0260.081
    Chinacase10.0520.0210.0770.1140.0610.3120.0960.0930.0730.216
    Chinacase10.090.2660.1540.0430.0620.3330.0590.0510.070.087
    Chinacase10.10.0460.0860.020.030.0450.0790.0320.0420.076
    Chinacase10.0820.030.0280.0070.0590.0070000.001
    Chinacase10.080.0290.0550.0290.0740.01300.0080.010.021
    Chinacase10.0320.1130.4050.0940.160.2770.1650.1850.5540.108
    Chinacase10.0060.0510.0920.1220.1040.2010.1480.1670.1640.055
    Chinacase10.0740.1130.1720.0780.430.140.4740.0850.2860.062
    Chinacase10.0960.0990.0850.0510.0940.0640.1310.0290.1250.055
    Chinacase10.140.0040.1190.0870.0980.0970.1330.0750.140.089
    Chinacase10.1820.0970.0530.0520.110.20.0220.04300.062
    Chinacase10.080.1060.1720.0690.090.1270.2050.1220.0360.134
    Chinacase10.090.0570.1010.1730.1340.20.2670.1220.1070.111
    Chinacase10.0640.080.1210.0130.050.02100.04400.06
    Chinacase10.0780.0590.0790.0780.040.0910.0910.0640.060.072
    Chinacase10.0360.070.240.0720.1180.0690.1090.090.130.103
    Chinacase10.0120.1240.2210.1380.1170.340.1060.0760.2030.137
    Chinacase10.0220.2070.2350.1130.2770.7610.7880.0770.3150.189
    Chinacase10.0160.1080.0880.1530.1580.1350.210.1310.1070.114
    Chinacase100.0740.0850.1940.4850.2570.2520.1210.3640.117
    Chinacase10.1380.2960.1490.1760.1840.3980.1950.1120.3610.082
    Chinacase10.1280.0910.1190.1850.1570.1910.1090.1040.1120.095
    Chinacase10.1040.1250.1540.2110.1650.1220.1460.0910.060.151
    Chinacase10.0740.0740.0620.0510.1680.2110.1630.0360.0940.143
    Chinacase10.2320.20.1180.2930.2850.4590.1160.260.140.103
    Chinacase10.1920.2690.3530.1260.2160.1530.3010.1250.1980.289
    Chinacase10.1040.1110.3320.3550.1020.1220.3310.0690.120.163
    Chinacase10.220.1990.1940.090.1980.4110.2470.1670.3930.137
    Chinacase10.090.1570.1150.1630.1651.7060.3380.2230.2130.224
    Chinacase10.0720.1650.2610.1240.5730.3180.2670.1120.2080.163
    Chinacase10.20.2130.1910.6450.2530.1570.4840.3160.4370.16
    Chinacase10.0060.0610.2090.1910.2820.2850.1753.7430.2370.118
    Chinacase10.0920.1430.0660.0730.1220.0970.1850.0480.060.06
    Chinacase10.1660.0210.0620.1780.1490.120.2790.1390.1590.095
    Chinacase10.2140.070.1390.1590.3470.1470.4220.1670.4390.073
    Chinacase10.1560.1380.180.1650.290.4930.5430.1350.0520.149
    Chinacase10.0740.1050.040.1260.0020.028-0.010.14700.043
    Chinacase10.1820.1790.1120.0620.1120.0890.3510.0640.0520.141
    Chinacase10.10.1020.2110.3890.3710.2050.5140.230.5770.156
    Chinacase10.0260.0480.2490.2160.1650.1060.1930.260.140.081
    Chinacase10.050.1110.0620.1140.1540.0640.1090.1130.0730.092
    Chinacase10.0840.2560.3970.1250.2590.2390.4770.6840.3930.225
    Chinacase10.0580.1350.0990.2330.1550.0960.3040.1130.1950.109
    Chinacase100.0710.2450.0810.1260.0660.0940.0640.0910.074
    Chinacase10.0280.1730.160.090.0580.1440.1280.120.0780.053
    Chinacase10.0260.0050.1250.1170.0880.1060.1830.07800.092
    Chinacase10.2340.1160.1170.0730.0190.1350.0860.07600.223
    Chinacase10.270.1990.1930.1470.1710.4460.3680.1120.2370.153
    Chinacase10.1320.09
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