need in 4 hours. 350 words

In Inaba & Cohen, the authors describe pathways, theories, and factors involved in substance abuse and addiction. Dr. Lyles in the AACC video also presents biological foundations of addiction. What do you believe are the 3 most important aspects in the development of substance abuse and addiction? Why did you choose those 3 aspects? How and to what extent are those aspects influenced by biological factors?