Immediate-release medications quickly deliver their drug content, with the maximum concentration reached in a

profiletutor4helpyou
 (Not rated)
 (Not rated)
Chat

Immediate-release medications quickly deliver their drug content, with the maximum concentration reached in a short time; sustained-release medications, on the other hand, take longer to reach maximum concentration. As part of a study, immediate-release codeine (irc) was compared with sustained-release codeine (src) using 13 healthy patients. The patients were randomly assigned to one of the two types of codeine and treated for 2.5 days; after a 7-day wash-out period, each patient was given the other type of codeine. Thus, each patient received both types. The total amount (A) of drug available over the life of the treatement in (ng . mL)/hr follow:

 

Patient1234567
Airc1091.31064.51281.11921.41649.91423.61308.4
Asrc1308.51494.21382.21978.32004.6*1211.1
        
Patient89101112  
Airc1192.1766.2978.61618.9582.9  
Asrc1002.4866.61345.8979.2576.3  
Source: http://exploringdata.cqu.edu.au/ws_coedn.htm

 

a. Explain why this is a paired-difference design.

b. What adjustmet is needed since there is no Asrc for patient 6?

 

Is there is a significant difference in the total amount of drug available over the life of the treatment?

c. Check the test assumptions and describe your findings.

d. Test the claim using α = 0.05.

    • 7 years ago
    Immediate-release medications quickly deliver their drug content, with the maximum concentration reached in a
    NOT RATED

    Purchase the answer to view it

    blurred-text
    • attachment
      post_21.docx
    • attachment
      post_22.xlsx