DNA sequencing and replication

What are the steps involved and the enzymes used in DNA replication? In your opinion, can a disorder result from the malfunction of any enzyme used during DNA replication? If yes, identify any one disorder and explain how it is caused. If no, why?

Can a disease result from a mutation in a transcription factor? If so, provide at least one example, naming the transcription factor, the mutation, and the congenital defect that arises.