Biochemistry -- Paper on Hemoglobin

I have an 8 page paper due on Hemoglobin. The following is an outline of what it can include but doesn't have to. It's just to give you an idea. I repeat, the paper DOES NOT have to follow this format.

What hemoglobin is

The protein formation – Alpha & Beta

How they work

Composition of hemoglobin

Main hemoglobin structure

Amino acid sequence

2 Chains - one alpha with 141 amino acids and one beta with 146 acids

Where the protein originally comes from

Hemoglobin being a protein and also called a polypeptide chain made up of subunits, which are amino acids that have linked with peptide bonds

Polypeptides forming due to the variety of amino acids in forming chains

Brief overview of 20 amino acids found in proteins

Hemoglobin’s affinity to oxygen and carbon dioxide
   -Hemoglobins ability to carry O2 lies in its structure, four subunits
   - Carbon monoxide having a stronger affinity for hemoglobin than oxygen
              - Why
   - Oxygen transport in the blood
   -Hemoglobin affinity for oxygen at high altitudes

Hemoglobin and X-ray crystallography

Key role x-ray crystallography has been in understanding the relationship between physiological function and protein structure

X-ray analysis of hemoglobin

Hemoglobins importance in basic theories about allosteric protein behavior

Brief discussion of John Kendrew and Max Perutz and the Nobel Prize they received for their work in determining the 3D structure of protein using x-ray crystallography

Hemoglobin cooperative binding with oxygen

Explain the physiological significance of cooperative binding of oxygen by hemoglobin

Oxygen binding changing the quaternary structure of hemoglobin

Various diseases related to hemoglobin

Sickle cell

Thalassemia

Porphyria

Enlarged spleen

Vasculitis