unit 2 discussion

Pharmacokinetics and Pharmacodynamics

Discuss the difference between pharmacokinetics and pharmacodynamics.

Discuss the metabolism, absorption, bioavailability, and excretion.

· Give an example of how each can be impacted (medical condition, body habitus, route of administration, etc.)

Discuss half-life elimination and influences that can alter it.

Rubric Title:

MSN 30 Point Discussion Rubric

Discussion Instructions: You must post your initial response to the discussion topic before reviewing your classmates’ responses.

Criteria 1	Level III Max Points Points: 12	Level II Max Points Points: 9	Level I Max Points Points: 6	Not Present 0 Points
Initial Response to Discussion Topic(s) & Content Quality (40%)	· The initial response to the discussion topic(s) meets all requirements and has no issues in its content. · Supports discussion concepts through personal experience and evidence-based information. · The initial response to the discussion topic(s) includes original thoughts, opinions, or ideas.	· The initial response to the discussion topic(s) meets most requirements and has some issues in its content. · Supports discussion concepts through personal experience and evidence-based information. · The initial response to the discussion topic(s) includes original thoughts, opinions, or ideas.	· The initial response to the discussion topic(s) meets minimum requirements and has issues in its content. · Supports discussion concepts through personal experience and evidence-based information. · The initial response to the discussion topic(s) includes original thoughts, opinions, or ideas.	No initial post or does not meet criteria
Criteria 2	Level III Max Points Points: 6	Level II Max Points Points: 4.5	Level I Max Points Points: 3	Not Present 0 Points
Timeliness of Initial Response to the Discussion Topics (20%)	· Provides an initial post that responds to the discussion topic question(s) by Saturday at 11:59 PM ET.	· N/A	· N/A	No initial post or does not meet criteria
Criteria 3	Level III Max Points Points: 6	Level II Max Points Points: 4.5	Level I Max Points Points: 3	Not Present 0 Points
Engagement in Social Learning (20%)	· Posts on three or more different days during the unit. · The replies to others ask follow-up questions or provide additional ideas that expand on the topic.	· Posts on two different days during the unit. · The replies to others ask follow-up questions or provide additional ideas that expand on the topic.	· Posts are only on one day during the unit. · The replies to others do not ask follow-up questions or provide additional ideas that expand on the topic.	No posts or does not meet criteria
Criteria 4	Level III Max Points Points: 6	Level II Max Points Points: 4.5	Level I Max Points Points: 3	Not Present 0 Points
Format/Style/APA/ Citations (20%)	· Displays college-level writing in Standard English (includes spelling, grammar, and punctuation). · Includes APA style in-text style citations, where appropriate, and a list of references when required. · References are relevant to the content and published within the last five years or are primary sources.	· Displays college-level writing in Standard English (includes spelling, grammar, and punctuation). One or two errors are noted. · Includes APA style in-text style citations, where appropriate, and a list of references when required. One or two errors are noted. · References are relevant to the content and published within the last five years or are primary sources.	· Displays college-level writing in Standard English (includes spelling, grammar, and punctuation). Three or more errors noted. · Includes APA style in-text style citations, where appropriate, and a list of references when required. Three or more errors noted. · References are not relevant to the content and/or not published within the last five years	No posts or does not meet criteria
Maximum Total Points	30	22.5	15	0
Minimum Total Points	23 points minimum	16 points minimum	1 point minimum	0

Updated December 2023

Unit 1 Reading

Textbook Reading:

Fast Facts: Chapters 3 & 4

Journal Reading:

Deodhar, M., Al Rihani, S. B., Arwood, M. J., Darakjian, L., Dow, P., Turgeon, J., & Michaud, V. (2020). Mechanisms of CYP450 Inhibition: Understanding Drug-Drug Interactions Due to Mechanism-Based Inhibition in Clinical Practice. Pharmaceutics, 12(9), 846. https://doi.org/10.3390/pharmaceutics12090846

Additional Resources:

· Unit 33 (Human Biology), Lesson 2: Neuron and the nervous system.  Khan Academy

https://www.khanacademy.org/science/biology

· YouTube: Cytochrome P450 Inducers and Inhibitors Mnemonic and Table | CYP450 SICKFACES & CRAP GPS - YouTube

Approximately 4 minutes

· YouTube: Pharmacokinetics: Absorption, Distribution, Metabolism & Excretion - YouTube

Approximately 14 minutes

· YouTube: Agonists VS partial agonists VS inverse agonists VS antagonists - YouTube

Approximately 4:30 in length

Unit 2 Reading

Textbook Reading:

Fast Facts: Chapters 3 & 4

Journal Reading:

Deodhar, M., Al Rihani, S. B., Arwood, M. J., Darakjian, L., Dow, P., Turgeon, J., & Michaud, V. (2020). Mechanisms of CYP450 Inhibition: Understanding Drug-Drug Interactions Due to Mechanism-Based Inhibition in Clinical Practice. Pharmaceutics, 12(9), 846. https://doi.org/10.3390/pharmaceutics12090846

Additional Resources:

· Unit 33 (Human Biology), Lesson 2: Neuron and the nervous system.  Khan Academy

https://www.khanacademy.org/science/biology

· YouTube: Cytochrome P450 Inducers and Inhibitors Mnemonic and Table | CYP450 SICKFACES & CRAP GPS - YouTube

Approximately 4 minutes

· YouTube: Pharmacokinetics: Absorption, Distribution, Metabolism & Excretion - YouTube

Approximately 14 minutes

· YouTube:  Agonists VS partial agonists VS inverse agonists VS antagonists - YouTube

Approximately 4:30 in length

Unit 3 Reading

Textbook Reading:

· Fast Facts: Chapter 5

· DSM 5- TR: pages 177-214

· Carlat: Section 3, chapter 19 & 23

Additional Resources:

· YouTube: Memorable Psychiatry: Depression & Dysthymia Mnemonics (Memorable Psychiatry Lecture) - YouTube  

Approximately 14 minutes 

· YouTube: Rhesus Medicine: Serotonin Syndrome Explained (Serotonin Toxicity) - YouTube

Approximately 7 minutes 

Unit 4 Reading

Textbook Reading:

· Fast Facts: Chapter 6

· DSM 5- TR: pages 215-262

· Carlat: Section III Chapters 19 & 25

Additional Resources:

· YouTube: Memorable Psychiatry: Anxiety Disorders Mnemonics (Memorable Psychiatry Lecture) - YouTube

Approximately 16 minutes

Unit 5 Reading

Textbook Reading:

· Fast Facts: Chapter 7

· DSM 5- TR: pages 101-138, 807-820

· Carlat: Section III, chapters 19 & 27

Additional Resources:

· YouTube: Memorable Psychiatry: Psychosis & Schizophrenia Mnemonics (Memorable Psychiatry Lecture) - YouTube

Approximately 17 minutes

· YouTube: Memorable Psychiatry & Neurology:  Antipsychotics Mnemonics (Memorable Psychopharmacology Lecture 4) - YouTube

Approximately 23 minutes

· YouTube: Dirty Medicine: Schizophrenia vs. Schizophreniform vs. Schizoaffective vs. Schizoid vs. Schizotypal - YouTube

Approximately 13 minutes

· YouTube: Rhesus Medicine: Neuroleptic Malignant Syndrome (NMS) Explained - YouTube

Approximately 8 minutes

Unit 6 Reading

Textbook Reading:

· Fast Facts: Chapters 8

· DSM 5- TR: pages 139-176

· Carlat: Section III, chapters 19 & 24

Additional Resources:

· YouTube: Memorable Psychiatry: Mania & Bipolar Disorder Mnemonics (Memorable Psychiatry Lecture) - YouTube

Approximately 17 minutes

· YouTube: Memorable Psychiatry & Neurology: Mood Stabilizers and Anxiolytics Mnemonics (Memorable Psychopharmacology Lectures 5 & 6) - YouTube

Approximately 22 minutes 

Unit 7 Reading

Textbook Reading:

· Fast Facts: Chapter 3

· DSM 5- TR: Substance-Related Disorders (pages 545-665)

· Carlat: Section III, Chapters 19 & 26

Additional Resources:

· TIP 63 SAMHSA

· AUD Brief Guide

· Drug Abuse: https://www.drugabuse.gov/sites/default/files/Commonly-Used-Drugs-Charts_final_June_2020_optimized.pdf

· Drug Abuse: https://www.drugabuse.gov/sites/default/files/nida_commonlyuseddrugs_final_printready.pdf

· YouTube: Memorable Psychiatry & Neurology: Addiction and Substance Use Disorder Mnemonics (Memorable Psychiatry Lecture) - YouTube

Approximately 14 minutes

· From SAMHSA.gov- additional resources can be found here

Including veterans, homeless population, culturally based care, women, etc.

· Alcohol Use Disorder Guide

· Chronic Pain & Addiction

· Stimulant Use Disorder

· TIP 42

Unit 8 Reading

Textbook Reading:

· Fast Facts: Chapters 9 & 10

· DSM 5- TR:

· Neurocognitive Disorders (pages 667-732)

· Gender Dysphoria (pages 511-520)

· ADHD 68-85

· Carlat: Section III, Chapters 19, 28, 30

Additional Resources:

· YouTube: Memorable Psychiatry & Neurology: Analgesics, Stimulants, and Antidementia Drugs Mnemonics (Memorable Psychopharmacology Lectures 7-9) - YouTube

Approximately 15 minutes

· YouTube: Memorable Psychiatry & Neurology: Other Dementias: Vascular Dementia, Dementia with Lewy Bodies, Frontotemporal Dementia (Memorable Psychiatry Lecture) - YouTube

Approximately 14 minutes

· YouTube: Memorable Psychiatry & Neurology: Attention Deficit Hyperactivity Disorder (ADHD) Mnemonics (Memorable Psychiatry Lecture) - YouTube

Approximately 13 minutes

· Transgender Youth

Unit 9 Reading

Textbook Reading:

· Fast Facts: Chapters 1 & 2

· DSM 5- TR: pages 5-28

· Carlat: Section II & IV

Additional Resources:

· YouTube: NP School Tips: NP SCHOOL CLINICAL TIPS - YouTube

Approximately 20 minutes

Unit 10 Reading

Textbook Reading:

· Fast Facts: Chapter 11 & 12

· DSM 5- TR: pages 407-476

Additional Resources:

· YouTube: Memorable Psychiatry & Neurology: Sleep and Sleep Disorders (Insomnia, Narcolepsy, and More) Mnemonics (Memorable Psychiatry Lecture) - YouTube

Approximately 22 minutes

· YouTube: Psych Explained: Sleep Stages, Sleep Cycle, and the Biology of Sleep - YouTube

Approximately 22 minutes

· YouTube: Sleep Hygiene: Train Your Brain to Fall Asleep and Sleep Better - YouTube

Approximately 8 minutes