OSH Unit VIII
Aldrich - W332615 Page 1 of 12
The life science business of Merck KGaA, Darmstadt, Germany
operates as MilliporeSigma in the US and Canada
SAFETY DATA SHEET
Version 8.4 Revision Date 09/09/2021
Print Date 05/14/2022
SECTION 1: Identification of the substance/mixture and of the company/undertaking
1.1 Product identifiers
Product name : Acetone
Product Number : W332615
Brand : Aldrich
Index-No. : 606-001-00-8
CAS-No. : 67-64-1
1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Synthesis of substances
1.3 Details of the supplier of the safety data sheet
Company : Sigma-Aldrich Inc.
3050 SPRUCE ST
ST. LOUIS MO 63103
UNITED STATES Telephone : +1 314 771-5765
Fax : +1 800 325-5052
1.4 Emergency telephone
Emergency Phone # : 800-424-9300 CHEMTREC (USA) +1-703-
527-3887 CHEMTREC (International) 24
Hours/day; 7 Days/week
SECTION 2: Hazards identification
2.1 Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
Flammable liquids (Category 2), H225
Eye irritation (Category 2A), H319
Specific target organ toxicity - single exposure (Category 3), Central nervous system, H336
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 GHS Label elements, including precautionary statements
Pictogram
Signal word Danger
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Hazard statement(s)
H225 Highly flammable liquid and vapor.
H319 Causes serious eye irritation.
H336 May cause drowsiness or dizziness. Precautionary statement(s)
P210 Keep away from heat/ sparks/ open flames/ hot surfaces. No
smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P241 Use explosion-proof electrical/ ventilating/ lighting/ equipment.
P242 Use only non-sparking tools.
P243 Take precautionary measures against static discharge.
P261 Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P264 Wash skin thoroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/ eye protection/ face protection.
P303 + P361 + P353 IF ON SKIN (or hair): Take off immediately all contaminated
clothing. Rinse skin with water/ shower.
P304 + P340 + P312 IF INHALED: Remove person to fresh air and keep comfortable
for breathing. Call a POISON CENTER/ doctor if you feel unwell.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P337 + P313 If eye irritation persists: Get medical advice/ attention.
P370 + P378 In case of fire: Use dry sand, dry chemical or alcohol-resistant
foam to extinguish.
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
P403 + P235 Store in a well-ventilated place. Keep cool.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal
plant.
2.3 Hazards not otherwise classified (HNOC) or not covered by GHS - none
SECTION 3: Composition/information on ingredients
3.1 Substances
Formula : C3H6O
Molecular weight : 58.08 g/mol
CAS-No. : 67-64-1
EC-No. : 200-662-2
Index-No. : 606-001-00-8 Component Classification Concentration
acetone
Flam. Liq. 2; Eye Irrit. 2A;
STOT SE 3; H225, H319,
H336
Concentration limits:
>= 20 %: STOT SE 3,
H336;
<= 100 %
Aldrich - W332615 Page 3 of 12
The life science business of Merck KGaA, Darmstadt, Germany
operates as MilliporeSigma in the US and Canada
For the full text of the H-Statements mentioned in this Section, see Section 16.
SECTION 4: First aid measures
4.1 Description of first-aid measures
General advice
Consult a physician. Show this material safety data sheet to the doctor in attendance.Move
out of dangerous area.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration.
Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Do NOT induce vomiting. Never give anything by mouth to an unconscious person. Rinse
mouth with water. Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
SECTION 5: Firefighting measures
5.1 Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
5.3 Advice for firefighters
Wear self-contained breathing apparatus for firefighting if necessary.
5.4 Further information
Use water spray to cool unopened containers.
SECTION 6: Accidental release measures
6.1 Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid breathing vapors, mist or gas. Ensure adequate
ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of
vapors accumulating to form explosive concentrations. Vapors can accumulate in low
areas.
For personal protection see section 8.
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The life science business of Merck KGaA, Darmstadt, Germany
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6.2 Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-
brushing and place in container for disposal according to local regulations (see section
13).
6.4 Reference to other sections
For disposal see section 13.
SECTION 7: Handling and storage
7.1 Precautions for safe handling
Advice on safe handling
Avoid contact with skin and eyes. Avoid inhalation of vapor or mist.
Advice on protection against fire and explosion
Use explosion-proof equipment.Advice on protection against fire and explosion
Keep away from sources of ignition - No smoking.Take measures to prevent the build up of
electrostatic charge.
Hygiene measures
Handle in accordance with good industrial hygiene and safety practice. Wash hands before
breaks and at the end of workday.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Keep container tightly closed in a dry and well-ventilated place. Containers which are
opened must be carefully resealed and kept upright to prevent leakage.
Storage class
Storage class (TRGS 510): 3: Flammable liquids
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Ingredients with workplace control parameters
Component CAS-No. Value Control
parameters
Basis
acetone
67-64-1
TWA 250 ppm
USA. ACGIH Threshold Limit
Values (TLV)
Remarks Not classifiable as a human carcinogen STEL 500 ppm
USA. ACGIH Threshold Limit
Values (TLV) Not classifiable as a human carcinogen
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TWA 250 ppm
590 mg/m3
USA. NIOSH Recommended
Exposure Limits TWA 1,000 ppm
2,400 mg/m3
USA. Occupational Exposure
Limits (OSHA) - Table Z-1
Limits for Air Contaminants STEL 1,000 ppm
2,400 mg/m3
USA. OSHA - TABLE Z-1 Limits
for Air Contaminants -
1910.1000 TWA 750 ppm
1,800 mg/m3
USA. OSHA - TABLE Z-1 Limits
for Air Contaminants -
1910.1000 C 3,000 ppm
California permissible exposure
limits for chemical
contaminants (Title 8, Article
107) PEL 500 ppm
1,200 mg/m3
California permissible exposure
limits for chemical
contaminants (Title 8, Article
107) STEL 750 ppm
1,780 mg/m3
California permissible exposure
limits for chemical
contaminants (Title 8, Article
107)
Biological occupational exposure limits
Component CAS-No. Parameters Value Biological
specimen
Basis
acetone
67-64-1
Acetone 25 mg/l Urine ACGIH -
Biological
Exposure Indices
(BEI)
Remarks End of shift (As soon as possible after exposure ceases)
Predicted No Effect Concentration (PNEC)
Compartment Value
Soil 33.3 mg/kg
Sea water 1.06 mg/l
Fresh water 10.6 mg/l
Sea sediment 3.04 mg/kg
Fresh water sediment 30.4 mg/kg
Onsite sewage treatment plant 100 mg/l
8.2 Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands
before breaks and at the end of workday.
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and
approved under appropriate government standards such as NIOSH (US) or EN
166(EU).
Aldrich - W332615 Page 6 of 12
The life science business of Merck KGaA, Darmstadt, Germany
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Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove
removal technique (without touching glove's outer surface) to avoid skin contact
with this product. Dispose of contaminated gloves after use in accordance with
applicable laws and good laboratory practices. Wash and dry hands. Full contact
Material: butyl-rubber
Minimum layer thickness: 0.3 mm
Break through time: 480 min
Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) Splash contact
Material: butyl-rubber
Minimum layer thickness: 0.3 mm
Break through time: 480 min
Material tested:Butoject® (KCL 897 / Aldrich Z677647, Size M) data source: KCL GmbH, D-36124 Eichenzell, phone +49 (0)6659 87300, e-mail
sales@kcl.de, test method: EN374
If used in solution, or mixed with other substances, and under conditions which
differ from EN 374, contact the supplier of the EC approved gloves. This
recommendation is advisory only and must be evaluated by an industrial hygienist
and safety officer familiar with the specific situation of anticipated use by our
customers. It should not be construed as offering an approval for any specific use
scenario. Body Protection
Impervious clothing, Flame retardant antistatic protective clothing., The type of
protective equipment must be selected according to the concentration and amount
of the dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-
face respirator with multi-purpose combination (US) or type AXBEK (EN 14387)
respirator cartridges as a backup to engineering controls. If the respirator is the sole
means of protection, use a full-face supplied air respirator. Use respirators and
components tested and approved under appropriate government standards such as
NIOSH (US) or CEN (EU).
Control of environmental exposure
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
SECTION 9: Physical and chemical properties
9.1 Information on basic physical and chemical properties
a) Appearance Form: liquid, clear
Color: colorless
b) Odor No data available
c) Odor Threshold No data available
d) pH No data available
e) Melting
point/freezing point
Melting point/range: -94 °C (-137 °F) - lit.
f) Initial boiling point
and boiling range
56 °C 133 °F at 1,013 hPa - lit.
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g) Flash point -17.0 °C (1.4 °F) - closed cup
h) Evaporation rate No data available
i) Flammability (solid,
gas)
No data available
j) Upper/lower
flammability or
explosive limits
Upper explosion limit: 13 %(V)
Lower explosion limit: 2 %(V)
k) Vapor pressure 533.3 hPa at 39.5 °C (103.1 °F)
245.3 hPa at 20.0 °C(68.0 °F)
l) Vapor density No data available
m) Density 0.791 g/cm3 at 25 °C (77 °F) - lit.
Relative density No data available
n) Water solubility completely miscible
o) Partition coefficient:
n-octanol/water
log Pow: -0.24
p) Autoignition
temperature
465.0 °C (869.0 °F)
q) Decomposition
temperature
No data available
r) Viscosity No data available
s) Explosive properties No data available
t) Oxidizing properties No data available
9.2 Other safety information
Surface tension 23.2 mN/m at 20.0 °C (68.0 °F)
SECTION 10: Stability and reactivity
10.1 Reactivity
No data available
10.2 Chemical stability
Stable under recommended storage conditions.
10.3 Possibility of hazardous reactions
Vapors may form explosive mixture with air.
10.4 Conditions to avoid
Heat, flames and sparks.
10.5 Incompatible materials
Bases, Oxidizing agents, Reducing agents, Acetone reacts violently with phosphorous
oxychloride.
10.6 Hazardous decomposition products
In the event of fire: see section 5
Aldrich - W332615 Page 8 of 12
The life science business of Merck KGaA, Darmstadt, Germany
operates as MilliporeSigma in the US and Canada
SECTION 11: Toxicological information
11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - female - 5,800 mg/kg
Remarks: (ECHA)
LC50 Inhalation - Rat - 4 h - 76 mg/l
Remarks: Unconsciousness
Drowsiness
Dizziness
(External MSDS)
LD50 Dermal - Rabbit - 20,000 mg/kg
Remarks: (IUCLID)
No data available
Skin corrosion/irritation
Skin - Rabbit
Result: Mild skin irritation - 24 h
(Draize Test)
Remarks: (RTECS)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Eye irritation - 24 h
(Draize Test)
Remarks: (RTECS)
Respiratory or skin sensitization
Maximization Test - Guinea pig
Result: Not a skin sensitizer.
Remarks: (ECHA)
Chronic exposure may cause dermatitis.
Germ cell mutagenicity
Test Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 473
Result: negative
Test Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: Mouse lymphoma test
Metabolic activation: without metabolic activation
Method: OECD Test Guideline 476
Result: negative
Carcinogenicity
IARC: No ingredient of this product present at levels greater than or equal to 0.1% is
identified as probable, possible or confirmed human carcinogen by IARC.
NTP: No ingredient of this product present at levels greater than or equal to 0.1% is
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identified as a known or anticipated carcinogen by NTP.
OSHA: No component of this product present at levels greater than or equal to 0.1% is
on OSHA’s list of regulated carcinogens.
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
Inhalation - May cause drowsiness or dizziness. - Narcotic effects
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
11.2 Additional Information
RTECS: AL3150000
To the best of our knowledge, the chemical, physical, and toxicological properties have not
been thoroughly investigated. After absorption:
Headache
Salivation
Nausea
Vomiting
Dizziness
narcosis
Coma
Other dangerous properties can not be excluded.
Handle in accordance with good industrial hygiene and safety practice.
Kidney - Irregularities - Based on Human Evidence
Skin - Dermatitis - Based on Human Evidence
Kidney - Irregularities - Based on Human Evidence
Skin - Dermatitis - Based on Human Evidence
SECTION 12: Ecological information
12.1 Toxicity Toxicity to fish flow-through test LC50 - Pimephales promelas (fathead minnow) -
6,210 mg/l - 96 h
(OECD Test Guideline 203) Toxicity to daphnia
and other aquatic
invertebrates
static test LC50 - Daphnia pulex (Water flea) - 8,800 mg/l - 48 h
Remarks: (ECHA)
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Toxicity to algae static test NOEC - M.aeruginosa - 530 mg/l - 8 d
(DIN 38412)
Remarks: (maximum permissible toxic concentration)
(IUCLID)
Toxicity to bacteria static test EC50 - activated sludge - 61.15 mg/l - 30 min
(OECD Test Guideline 209)
12.2 Persistence and degradability
Biodegradability aerobic - Exposure time 28 d
Result: 91 % - Readily biodegradable.
(OECD Test Guideline 301B) Biochemical Oxygen
Demand (BOD)
1,850 mg/g
Remarks: (IUCLID) Chemical Oxygen
Demand (COD)
2,070 mg/g
Remarks: (IUCLID) Theoretical oxygen
demand
2,200 mg/g
Remarks: (Lit.)
12.3 Bioaccumulative potential
Does not bioaccumulate.
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not
conducted
12.6 Other adverse effects
SECTION 13: Disposal considerations
13.1 Waste treatment methods
Product
Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra
care in igniting as this material is highly flammable. Offer surplus and non-recyclable
solutions to a licensed disposal company. Contact a licensed professional waste disposal
service to dispose of this material.
Contaminated packaging
Dispose of as unused product.
SECTION 14: Transport information
DOT (US)
UN number: 1090 Class: 3 Packing group: II
Proper shipping name: Acetone
Reportable Quantity (RQ): 5000 lbs
Poison Inhalation Hazard: No
IMDG
Aldrich - W332615 Page 11 of 12
The life science business of Merck KGaA, Darmstadt, Germany
operates as MilliporeSigma in the US and Canada
UN number: 1090 Class: 3 Packing group: II EMS-No: F-E, S-D
Proper shipping name: ACETONE
IATA
UN number: 1090 Class: 3 Packing group: II
Proper shipping name: Acetone
SECTION 15: Regulatory information
SARA 302 Components
No chemicals in this material are subject to the reporting requirements of SARA Title III,
Section 302.
SARA 313 Components
This material does not contain any chemical components with known CAS numbers that
exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section
313.
SARA 311/312 Hazards
Fire Hazard, Acute Health Hazard, Chronic Health Hazard
Massachusetts Right To Know Components
acetone
CAS-No.
67-64-1
Revision Date
1993-02-16
Pennsylvania Right To Know Components
acetone CAS-No.
67-64-1
Revision Date
1993-02-16
New Jersey Right To Know Components
acetone CAS-No.
67-64-1
Revision Date
1993-02-16
California Prop. 65 Components
This product does not contain any chemicals known to the State of California to cause
cancer, birth, or any other reproductive defects.
SECTION 16: Other information
Further information
Copyright 2020 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies
for internal use only.
The above information is believed to be correct but does not purport to be all inclusive
and shall be used only as a guide. The information in this document is based on the
present state of our knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any guarantee of the properties of
the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any
damage resulting from handling or from contact with the above product. See
www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional
terms and conditions of sale.
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product ordered. For further information please contact mlsbranding@sial.com. Version: 8.4 Revision Date: 09/09/2021 Print Date: 05/14/2022