Order 1106099: migraine
Abnormal changes in cortical activity in women with migraine between episodes
subject
Migraine group: 21 female migraine patients (mean age: 34.6 + 6.7 years), all with right hand, ranged from 1 year to 22 years.
Healthy control group: 10 females (mean age: 30.2 + 4.3 years), all of whom were right-handed, and their education degree matched that of the migraine group
task
Flip board
Is generated by
Direct（version 9; Microsoft Inc., Redmond, WA, USA）Brain X， The white board is made up of black and white children and yellow dots at the center ， The brightness of the white checkerboard is
80cd/m²， The flip frequency is
1HZ，（ There is a 600ms interval between the two stimuli and the duration of the stimulus is 400ms ）， The image was projected by a projector about 32cm from the subject's nasal roots ， Participants' perspectives and board into 30 °.
The standard set
Criteria for inclusion of migraine patients:
(1) According to the international classification of headache diseases edition 2 (ICHD).II) criteria for the diagnosis of unthreatened migraine and confirmed by neurologists
(2) Exclusion of other neurological diseases;
(3) The patient had no history of visual system and eye diseases
(4) Patients with the disease were not treated with migraine preventive drugs within 1 week before the test.
(5) No migraine occurred 72 hours before, on the day of and 24 hours after MEG examination
Inclusion criteria of healthy control group:
(1) No history of visual system-related diseases;
(2) No history of neuropsychiatric disorders
；
(3) His first-degree relatives had no history of migraine
。
Exclusion criteria for both groups:
Patients with metal implants (severely interfering with the brain magnetogram signal);
A history of other major neurological or psychiatric disorders ；
A history of extensive developmental disorders
；
A history of clinically significant systemic diseases
Cannot stay still during MEG recording and MR/scan
Don't move;
；
Subjects with claustrophobia or during pregnancy
DATA analysis ----No 1Morphology
（waveform）：VEFII Is the most stable of visual evoked potential composition, therefore, the main observation indexes for this experiment, the incubation period the VEFII approximately 2.5 -100 hz frequency (latency) is relatively more clearly and wave (Amplitude) interference factors, and can reflect the strength of the temporary only, reason is not included in the result analysis.
Result：
Result --waveform
The composition of VEF II was longer in the migraine group than in the healthy control group (HC)
122±3.02ms VS 118±3.78ms（p＜0.05）
trigger
Sensor level analysis
（Time–frequency analysis）
1.By Morlet continuous wavelet（CWT）polarity contour maps can be showed to Study the spatial characteristics of visual evoked potential
2. Measuring the energy characteristics of the visually induced magnetic field VEF: select the most representative channel and calculate the absolute wave energy of the VEF measured by its root-mean-square (the time window for measuring the wave energy is set to 0-200ms)
Source analysis （Wave Amp source imaging）
1. use wavelet-based beamformer to do the source analysis
2.main frequency range ：
Low frequency （5-100Hz）
High frequency （100-1000Hz）
Very high frequency （1000-2883hz）
result---Time–frequency analysis
As for Morlet continuous wavelet transform，in low frequency range ,we use sigma value to Improve time sensitivity
），while in high frequency range ,we use high sigma value to Improve frequency sensitivity
In the 5-100hz frequency band, it can be seen that at least 3 active components constitute an waveform, whose frequency is 5-30hz, and the strongest active frequency band is around 5-10hz
1
2
3
30HZ
In the 100-1000hz frequency band, it can be seen that the activation frequency caused by VEF is around 100-160hz
偏头痛患者组
健康对照组
In 1000-2883hz,we don’t see activation in both migraine group and HC group
（polarity contour maps）5-100HZ: this show difference of activation
HC
Migraine
100-1000HZ
HC
migraine
Source analysis 5-30HZ
Migraine –activation on both side of the visual cortex (16/21 on both side )
HC-activation more like to be only oneside of the visual cortex (2/10 on both side )
Source analysis （100-300Hz）
偏头痛患者
健康对照组
This explanation about why there is no activation in high frequency range can be used in discussion