WEEK 2 NOTE

Module 2 Weekly Note. Address each heading in the yellow outline note.

Read Chapter 2, pages 29-50. No reference needed.

Neurotransmitter Transporters as Targets of Drug Action 29

Classification and Structure 29

Monoamine Transporters (SLC6 Gene Family) as Targets of Psychotropic Drugs 31

Other Neurotransmitter Transporters (SLC6 and SLC1 Gene Families) as Targets of Psychotropic Drugs 34

Where Are the Transporters for Histamine and Neuropeptides? 35

Vesicular Transporters: Subtypes and Function 35

Vesicular Transporters (SLC18 Gene Family) as Targets of Psychotropic Drugs 35

G-Protein-Linked Receptors 36

Structure and Function 36

G-Protein-Linked Receptors as Targets of Psychotropic Drugs 36

Enzymes as Sites of Psychopharmacological Drug Action 45

Cytochrome P450 Drug Metabolizing Enzymes as Targets of Psychotropic Drugs 49

Summary 50