paper
War of the Worlds
1st line of defense
If that is breached…
Non-specific Response –
inflammation
Non-specific Response –
inflammation,
margination
&
diapedesis
Non-specific Response –
inflammation & ultrafiltration
Leukocytes & the innate
non-specific response
Leukocyte production
reminder
Non-specific Viral & Cancer
Response – interferon
Non-specific Viral & Cancer
Response –
Natural Killer Cells
(NK cells)
Assassins
with GENERAL instructions
Non-specific Response –
complement system
“exploding microbes”
Adaptive & Specific
“Acquired immunity”
SCIDS
SCIDS
Type: Gene Lymphocyte Phenotype
X-linked IL2RG T(-) B (+) NK (-)
Autosomal
ADA gene ADA T (-) B (-) NK (-)
Jak3 gene JAK3 T(-) B (+) NK (-)
IL-7R alpha IL7R alpha T (-) B (+) NK (+)
CD3 d or e CD3 d or e T (-) B (+) NK (+)
RAG1/RAG2 RAG1/RAG2 T (-) B (-) NK (+)
Artemis gene Artemis T (-) B (-) NK (+)
CD45 gene CD45 T (-) B (+) NK (+)
Cytotoxic T cells recognize
self-viral antigen complex
Upon costimulation with CD28 & MHC/antigen complex,
Cytotoxic T cells then give the
kiss of death – perforin
1st line of defense
Keratinocyte stimulates T cell maturation in the skin…and Langerhans provide the costimulator
Other T cells (beyond cytotoxic T cells)
* Helper T cells
A team effort
T cells and innate response in concert:
And that’s not all…
B cells – produce antibodies
B cells
B cells – plasma vs memory
B cells – antibody mediated specific
response
SCIDS treatment options
Science & Religion