wroksheet
CHAPTER 2
Nutrients: Ingestion to Energy Metabolism
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What happens to nutrients after they are ingested?
Digestion
Mastication
Enzymatic activity
Absorption
Transport
Assimilation and/or energy production
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Digestion: Anatomy and Functions of the Digestive System
Mouth (oral cavity)
Esophagus
Stomach
Small intestine
Large intestine
Rectum
Figure 2.1 Anatomy of the digestive system.
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Digestion: Salivary Glands
Salivary glands
Parotid
Sublingual
Submandibular
Secrete saliva
Moistens food
Contains enzymes
Figure 2.3 The salivary glands. The three pairs of salivary glands supply saliva, which moistens and lubricates food. Saliva also contains salivary enzymes that begin the digestion of starch.
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Digestion: Stomach
Muscular organ
Primary function: Digestion
Major secretions
Hydrochloric acid
Mucus
Digestive enzymes
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Digestion and Absorption: Small Intestine
Duodenum
Majority of digestion occurs here
Jejunum
Little digestion
Absorption
Ileum
Absorption
Figure 2.4 The small intestine. Secretions from the pancreas, liver, and gallbladder assist in digestion. All along the intestinal walls, nutrients are absorbed into blood and lymph. Undigested materials are passed on to the large intestine.
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Absorption: Surface of Small Intestine
Convoluted interior
Villi
Microvilli
Result: Increased surface area for absorption
Figure 2.5 The absorptive surface of the small intestine. To maximize the absorptive surface area, the small intestine is folded and lined with villi. You have a surface area the size of a tennis court packed into your gut.
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Absorption: Large Intestine
Colon
Ascending
Transverse
Descending
Rectum
Anus
Some absorption
Water – Potassium
Sodium – Vitamin K
Chloride
Figure 2.6 The large intestine. In the large intestine, bacteria break down dietary fiber and other undigested carbohydrates, releasing acids and gas. The large intestine absorbs water and minerals and forms feces for excretion.
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Absorption of Nutrients
Figure 2.7 Absorption of nutrients.
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Absorption: Mechanisms
Passive diffusion
Facilitated diffusion
Active transport
Endocytosis
Figure 2.8 Mechanisms for nutrient absorption. (A) Passive diffusion. Using passive diffusion, some substances easily move in and out of cells, either through protein channels or directly through the cell membrane. (B) Facilitated diffusion. Some substances need a little assistance to enter and exit cells. The transmembrane protein helps out by changing shape. (C) Active transport. Some substances need a lot of assistance to enter cells. Similar to swimming upstream, energy is needed for the substance to penetrate against an unfavorable concentration gradient. (D) Endocytosis. Cells can use their cell membranes to engulf a particle and bring it inside the cell. The engulfing portion of the membrane separates from the cell wall and encases the particle in a vesicle.
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Carbohydrates: Digestion
Mouth
Mastication
Amylase
Stomach
Churning
Acid
Small intestine
Sugar enzymes
Large intestine
Bacteria
Figure 2.12 Triglyceride digestion. Most triglyceride digestion takes place in the small intestine.
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Carbohydrates: Absorption
Most absorption occurs in small intestine.
Mechanisms
Facilitated diffusion: Fructose
Active transport: Glucose and galactose
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Carbohydrates: After Absorption
Transport via blood
Cellular uptake
Insulin
Glucose transporters
Fates
Storage
Conversion
Energy
Figure 2.9 Flow chart of glucose and other simple sugars immediately after a meal.
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Fats: Digestion
Mouth
Mastication
Lingual lipase
Stomach
Gastric lipase
Small intestines
Bile
Pancreatic lipase
Micelle formation
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Fats: Absorption
Occurs in small intestine
Mechanism
Passive diffusion
Very little fat makes it to large intestine
Steatorrhea
Crohn’s disease
Cystic fibrosis
Figure 2.13 Summary of lipid absorption.
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Fats: After Absorption
Transport
Lymph
Chylomicrons
Blood
Cellular uptake
Lipoprotein lipase
Fates
Storage
Energy
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Proteins: Digestion
Mouth
Mastication
Stomach
Churning
Acid denaturation
Small intestine
Proteases
Peptidases
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Proteins: Absorption
Occurs in small intestine
Mechanisms
Facilitated diffusion
Active transport
Very little makes it to large intestine
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Proteins: After Absorption (1 of 2)
Transport
Blood
Become part of amino acid pool
Fates
Body proteins
Conversion
Energy
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Proteins: After Absorption (2 of 2)
Figure 2.16 Amino acid pool turnover. Cells draw upon their amino acid pools to synthesize new proteins. These small pools turn over quickly and must be replenished by amino acids from dietary protein and degradation of body protein. Dietary protein supplies about one-third, and the break-down of body protein supplies about two-thirds of the roughly 300 grams of body protein synthesized daily. When dietary protein is inadequate, increased degradation of body protein replenishes the amino acid pool. This can lead to the breakdown of essential body tissue.
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Cellular Protein Synthesis
Transcription
DNA
mRNA
Translation
Transfer RNA
Amino acids
Figure 2.17 Protein synthesis. Ribosomes are our protein-synthesis factories. First, mRNA carries manufacturing instructions from DNA in the cell nucleus to the ribosomes. Then tRNA collects and delivers amino acids in the correct sequence.
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Digestion causes release from foods.
Absorption occurs in small and large intestines.
Vitamins, Minerals, and Water
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What is energy?
It is the entity that enables our bodies to perform work.
It has no shape.
It has no physical mass.
Our bodies rely on chemical energy.
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What is the body’s source of energy?
Macronutrients
Carbohydrates
Fats
Proteins
Body’s direct energy source
Adenosine triphosphate (ATP)
Figure 2.19 The ADP–ATP cycle. When extracting energy from nutrients, the formation of ATP from ADP + Pi captures energy. Breaking a phosphate bond in ATP to form ADP + Pi releases energy for biosynthesis and work.
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Adenosine Triphosphate (ATP)
Body’s energy source
Two high-energy bonds
Other phosphates
ADP
AMP
Figure 2.20 ATP, ADP, AMP, and high-energy phosphate bonds. Your body can readily use the energy in high-energy phosphate bonds. During metabolic reactions, phosphate bonds form or break to capture or release energy.
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Cell Structure and Organelles Necessary for ATP Production
Figure 2.22 Component parts of a typical cell.
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What are the three energy systems?
Phosphagen system
Anaerobic energy system
Aerobic energy system
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Comparison of the Three Energy Systems
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Metabolic Pathways
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Energy Nutrients
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Cellular ATP Production: The Metabolic Factory
Figure 2.23 Metabolic factory analogy of energy metabolism.
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Phosphagen Energy System
Stores of high-energy phosphates
ATP
Creatine phosphate (CP)
Also known as:
Immediate energy system
ATP-CP system
Figure 2.24 The ATP–CP energy system. To maintain relatively constant ATP levels during the first few seconds of a high-intensity activity, creatine phosphate releases energy and its phosphate (Pi) to regenerate ATP from ADP.
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Anaerobic Energy System
Involves only carbohydrates
Does not require oxygen
Also known as:
Anaerobic glycolysis
Figure 2.29 Anaerobic glycolysis.
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Aerobic Energy System
Involves all macronutrients
Requires oxygen
Also known as:
Oxidative system
Figure 2.30 Aerobic metabolism of the macronutrients.
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Carbohydrate Intake Impacts Protein Metabolism
Carbohydrates are an important energy source.
Low carbohydrate intake can result in muscle protein breakdown and loss of muscle mass.
Gluconeogenesis forms glucose from proteins.
Adequate carbohydrate intake spares muscle mass.
Figure 2.35 Gluconeogenesis. Liver and kidney cells make glucose from pyruvate by way of oxaloacetate. Gluconeogenesis is not the reverse of glycolysis. Although these pathways share many reactions, albeit in the reverse direction, gluconeogenesis must detour around the irreversible steps in glycolysis.
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Energy System Contributions to Activities of Varying Intensity (1 of 5)
The small storage pool of ATP is the source of energy whenever instantaneous energy is needed.
Figure 2.25 The three energy systems work together to meet the energy demands of any level of physical activity. Width of arrow denotes degree of energy contribution.
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Energy System Contributions to Activities of Varying Intensity (2 of 5)
During short bursts of intense activity (i.e., 100-m run), the phosphagen system is the main energy system that supplies the ATP pool.
Figure 2.25 The three energy systems work together to meet the energy demands of any level of physical activity. Width of arrow denotes degree of energy contribution.
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Energy System Contributions to Activities of Varying Intensity (3 of 5)
During longer-lasting sprint activities of lower intensity (e.g., 800-m run), the main supplier is the anaerobic system with help from the phosphagen and aerobic systems.
Figure 2.25 The three energy systems work together to meet the energy demands of any level of physical activity. Width of arrow denotes degree of energy contribution.
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Energy System Contributions to Activities of Varying Intensity (4 of 5)
During longer-lasting activities of even lower intensity (e.g., mile run), the main supplier becomes the aerobic system with help from the anaerobic system.
Figure 2.25 The three energy systems work together to meet the energy demands of any level of physical activity. Width of arrow denotes degree of energy contribution.
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Energy System Contributions to Activities of Varying Intensity (5 of 5)
During long-lasting activities of low intensity (i.e., any sustainable activity), the main supplier becomes the aerobic system with minimal help from the other systems.
Figure 2.25 The three energy systems work together to meet the energy demands of any level of physical activity. Width of arrow denotes degree of energy contribution.
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Summary: The Energy Systems Work Together to Meet ATP Demand
Figure 2.27 Regulation of endogenous fat and carbohydrate metabolism in relation to exercise duration and intensity.
Reproduced from Romijn JA, Coyle EF, Sidossis LS et al. Regulation of endogenous fat and carbohydrate metabolism in relation to exercise intensity and duration. J Physiol-Endocrinol Metab. 1993;265(3): E380-E391.
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