Testing to Find Relationships Among Many Variables

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Framingham Heart Study Longitudinal Data Documentation

The Framingham Heart Study is a long term prospective study of the etiology of cardiovascular disease among a population of free living subjects in the community of Framingham, Massachusetts. The Framingham Heart Study was a landmark study in epidemiology in that it was the first prospective study of cardiovascular disease and identified the concept of risk factors and their joint effects. The study began in 1948 and 5,209 subjects were initially enrolled in the study. Participants have been examined biennially since the inception of the study and all subjects are continuously followed through regular surveillance for cardiovascular outcomes. Clinic examination data has included cardiovascular disease risk factors and markers of disease such as blood pressure, blood chemistry, lung function, smoking history, health behaviors, ECG tracings, Echocardiography, and medication use. Through regular surveillance of area hospitals, participant contact, and death certificates, the Framingham Heart Study reviews and adjudicates events for the occurrence of Angina Pectoris, Myocardial Infarction, Heart Failure, and Cerebrovascular disease.

The enclosed dataset is a subset of the data collected as part of the Framingham study and includes laboratory, clinic, questionnaire, and adjudicated event data on 4,434 participants. Participant clinic data was collected during three examination periods, approximately 6 years apart, from roughly 1956 to 1968. Each participant was followed for a total of 24 years for the outcome of the following events: Angina Pectoris, Myocardial Infarction, Atherothrombotic Infarction or Cerebral Hemorrhage (Stroke) or death. (NOTE: Although the enclosed dataset contains Framingham data ‘as collected’ by Framingham investigators, specific methods were employed to ensure an anonymous dataset that protects patient confidentiality; therefore, this dataset is inappropriate for publication purposes).

The data is provided in Longitudinal form. Each participant has 1 to 3 observations depending on the number of exams the subject attended, and as a result there are 11,627 observations on the 4,434 participants. Event data for each participant has been added without regard for prevalent disease status or when examination data was collected. For example, consider the following participant:

RANDID age SEX time period prevchd mi_fchd timemifc

95148 52 2 0 1 0 1 3607

95148 58 2 2128 2 0 1 3607

95148 64 2 4192 3 1 1 3607

Participant 95148 entered the study (time=0 or period=1) free of prevalent coronary heart disease (prevchd=0 at period=1); however, during followup, an MI event occurred at day 3607 following the baseline examination. The MI occurred after the second exam the subject attended (period=2 or time=2128 days), but before the third attended exam (period=3 or time=4192 days). Since the event occurred prior to the third exam, the subject was prevalent for CHD (prevchd=1) at the third examination. Note that the event data (mi_fchd, timemifc) covers the entire followup period and does not change according to exam.

The following characteristics or risk factor data are provided in the dataset. Missing values in the dataset are indicated by a period (.). In SAS, missing values are numerically the smallest possible values (for example, <0 or < -99999999).

Variable Description Units Range or count

RANDID Unique identification number for each participant

2448 9999312

SEX Participant sex 1=Men 2=Women

n=5022 n=6605

PERIOD Examination Cycle 1=Period 1 2=Period 2 3=Period 3

n=4434 n=3930 n=3263

TIME Number of days since baseline exam 0-4854

AGE Age at exam (years) 32-81

SYSBP Systolic Blood Pressure (mean of last two of three measurements) (mmHg)

83.5-295

DIABP Diastolic Blood Pressure (mean of last two of three measurements) (mmHg)

30-150

BPMEDS Use of Anti-hypertensive medication at exam

0=Not currently used 1=Current Use

n=10090 n=944

CURSMOKE Current cigarette smoking at exam 0=Not current smoker 1=Current smoker

n=6598 n=5029

CIGPDAY Number of cigarettes smoked each day

0=Not current smoker 1-90 cigarettes per day

TOTCHOL Serum Total Cholesterol (mg/dL) 107-696

HDLC High Density Lipoprotein Cholesterol (mg/dL)

available for period 3 only

10-189

LDLC Low Density Lipoprotein Cholesterol (mg/dL)

available for period 3 only

20-565

BMI Body Mass Index, weight in kilograms/height meters squared

14.43-56.8

GLUCOSE Casual serum glucose (mg/dL) 39-478

DIABETES Diabetic according to criteria of first exam treated or first exam with casual glucose of 200 mg/dL or more

0=Not a diabetic 1=Diabetic

n=11097 n=530

Variable Description Units Range or count

HEARTRTE Heart rate (Ventricular rate) in beats/min

37-220

PREVAP Prevalent Angina Pectoris at exam 0=Free of disease 1=Prevalent disease

n=11000 n=627

PREVCHD Prevalent Coronary Heart Disease defined as pre-existing Angina Pectoris, Myocardial Infarction (hospitalized, silent or unrecognized), or Coronary Insufficiency (unstable angina)

0=Free of disease 1=Prevalent disease

n=10785 n=842

PREVMI Prevalent Myocardial Infarction 0=Free of disease 1=Prevalent disease

n=11253 n=374

PREVSTRK Prevalent Stroke 0=Free of disease 1=Prevalent disease

n=11475 n=152

PREVHYP Prevalent Hypertensive. Subject was defined as hypertensive if treated or if second exam at which mean systolic was >=140 mmHg or mean Diastolic >=90 mmHg

0=Free of disease 1=Prevalent disease

n=6283 n=5344

For Each participant the following event data is provided. For each type of event, ‘0' indicates the event did not occur during followup, and ‘1' indicates an event did occur during followup. Only the first event occurring during the interval of baseline (PERIOD=1) to end of followup is provided:

Variable name Description

ANGINA Angina Pectoris

HOSPMI Hospitalized Myocardial Infarction

MI_FCHD Hospitalized Myocardial Infarction or Fatal Coronary Heart Disease

ANYCHD Angina Pectoris, Myocardial infarction (Hospitalized and silent or unrecognized), Coronary Insufficiency (Unstable Angina), or Fatal Coronary Heart Disease

STROKE Atherothrombotic infarction, Cerebral Embolism, Intracerebral Hemorrhage, or Subarachnoid Hemorrhage or Fatal Cerebrovascular Disease

CVD Myocardial infarction (Hospitalized and silent or unrecognized), Fatal Coronary Heart Disease, Atherothrombotic infarction, Cerebral Embolism, Intracerebral Hemorrhage, or Subarachnoid Hemorrhage or Fatal Cerebrovascular Disease

HYPERTEN Hypertensive. Defined as the first exam treated for high blood pressure or second exam in which either Systolic is : 140 mmHg or Diastolic : 90mmHg

DEATH Death from any cause

TIMEAP Number of days from Baseline exam to first Angina during the followup or Number of days from Baseline to censor date. Censor date may be end of followup, death or last known contact date if subject is lost to followup

TIMEMI Defined as above for the first HOSPMI event during followup

TIMEMIFC Defined as above for the first MI_FCHD event during followup

TIMECHD Defined as above for the first ANYCHD event during followup

TIMESTRK Defined as above for the first STROKE event during followup

TIMECVD Defined as above for the first CVD event during followup

TIMEHYP Defined as above for the first HYPERTEN event during followup

TIMEDTH Number of days from Baseline exam to death if occurring during followup or Number of days from Baseline to censor date. Censor date may be end of followup, or last known contact date if subject is lost to followup

Note that defining Hypertensive requires exam participation and bias can therefore occur. Subjects attending exams regularly have a greater opportunity to be defined as hypertensive. Subjects not attending exams would be assumed to be free of hypertension. Since Hypertension is highly prevalent, this misclassification could potentially be large.

Defining Incident events

Frequently, epidemiologists need to define the population at risk for some disease or event outcome, and individuals who have previously had an event need to be excluded from the analysis so that only new or first events are counted. Incidence or first event rates can be calculated using any of the three examinations as a baseline exam. The variables PREVAP, PREVMI, PREVCHD, PREVSTRK, and PREVHYP will define the population at risk for the outcome of interest. For example, assume we are interested in incident hospitalized myocardial infarction or fatal coronary heart disease. Consider again participant 95148 and participants 477082 and 1140225 whose data are given below.

RANDID age SEX time period prevchd mi_fchd timemifc

95148 52 2 0 1 0 1 3607

95148 58 2 2128 2 0 1 3607

95148 64 2 4192 3 1 1 3607

477082 38 1 0 1 0 1 1718

477082 44 1 2119 2 1 1 1718

1140225 58 2 0 1 0 0 8766

1140225 64 2 2172 2 0 0 8766

1140225 69 2 4287 3 0 0 8766

Participants are often enrolled in an observational study without regard to past medical history. The study investigators will review the medical record to determine if the participant had any pre-existing disease at the time of the first study examination. If pre-existing disease is found, then the data for that subject will reflect prevalent disease at the first exam; however, the subject will continue to be followed for any new events. All participants, regardless of their prevalent disease status, will continue to be followed and events recorded until the study ends, the participant dies, or the participant cannot be contacted to ascertain their status (lost to followup). For participants who enter the study free of disease, the incident events are used to determine prevalent disease status at later exams. For the three participants above, none entered the study with prevalent disease and using period 1 as the baseline exam, the population at risk could be defined using code similiar to the SAS code below:

data work; set frmgham; if period=1 and prevchd=0;

The data would appear as the following:

RANDID age SEX time period prevchd mi_fchd timemifc

95148 52 2 0 1 0 1 3607

477082 38 1 0 1 0 1 1718

1140225 58 2 0 1 0 0 8766

The population at risk consists of all three participants (prevchd=0) and followup time for the event of hospitalized MI or fatal CHD would be the time indicated under TIMEMIFC. The first two participants (95148 and 477082) would be regarded as having an incident event during followup.

Likewise, the second examination or period=2 could also be used as a baseline exam. The full dataset can be subset to include only those at risk at the start of the second period. For example:

data work; set frmgham; if period=2 and prevchd=0;

Since time to event is provided as days since the first visit, a new time variable would need to be created so that number of days under study extends from the second exam until the end of followup:

newtime=timemifc-time;

The revised dataset that includes the population at risk beginning at period=2 and extends until the end of followup would be:

RANDID age SEX time period prevchd mi_fchd timemifc newtime

95148 58 2 2128 2 0 1 3607 1479

1140225 64 2 2172 2 0 0 8766 6594

The population at risk (those free of prevalent disease) now includes only participants 95148 and 1140225. The variable NEWTIME correctly reflects the number of days of followup from the second exam or period=2 until the first event or a censor point.

The same procedure can be used to define the third exam or period=3 as the baseline exam.

For more complex analyses, such as time-dependent analysis, or a counting process style of input, the user would have to subset the population to those free of disease at all exams and event data would have to be modified to reflect when the event occurred relative to the examinations. Consider the following SAS code which would modify the dataset to a counting process style of input for an analysis on the Hospitalized MI-Fatal CHD endpoint. The variable NEWEVNT is modified from MI_FCHD so that the event indicator is ‘1' only once for each participant. The variables TIME and ENDTIME define the interval the subject is at risk:

data analysis; set work; if prevchd=0;

proc sort data=analysis; by randid descending period;

data analysis; set analysis; by randid;

newevnt=mi_fchd;

retain exmtime;

if first.randid then do; endtime=timemifc; exmtime=time; end;

else do;

newevnt=0; endtime=exmtime;exmtime=time;

end;

proc sort data=analysis; by randid period;run;

The data would appear, for example, as follows for three participants :

RANDID age SEX period time endtime newevnt mi_fchd timemifc

11263 43 2 1 0 2178 0 1 5719

11263 49 2 2 2178 4351 0 1 5719

11263 55 2 3 4351 5719 1 1 5719

12629 63 2 1 0 8766 0 0 8766

9069458 42 2 1 0 4362 0 0 8766

9069458 54 2 3 4362 8766 0 0 8766

SAS PROC CONTENTS PROCEDURE ON FRAMINGHAM LONGITUDINAL DATASET

The CONTENTS Procedure

Data Set Name: WORK.FRMGHAM Observations: 11627

Member Type: DATA Variables: 38

Engine: V8 Indexes: 0

Created: 14:50 Tuesday, March 2, 2004 Observation Length: 304

Last Modified: 14:50 Tuesday, March 2, 2004 Deleted Observations: 0

Protection: Compressed: NO

Data Set Type: Sorted: NO

Label:

-----Engine/Host Dependent Information----

Data Set Page Size: 16384

Number of Data Set Pages: 220

First Data Page: 1

Max Obs per Page: 53

Obs in First Data Page: 35

Number of Data Set Repairs: 0

Release Created: 8.0202M0

Host Created: WIN_PRO

The CONTENTS Procedure

-----Variables Ordered by Position----

# Variable Type Len Label

1 SEX Num 4 SEX

2 RANDID Num 8 Random ID

3 totchol Num 8 Serum Cholesterol mg/dL

4 age Num 8 Age (years) at examination

5 sysbp Num 8 Systolic BP mmHg

6 diabp Num 8 Diastolic BP mmHg

7 cursmoke Num 8 Current Cig Smoker Y/N

8 cigpday Num 8 Cigarettes per day

9 bmi Num 8 Body Mass Index (kg/(M*M)

10 diabetes Num 8 Diabetic Y/N

11 bpmeds Num 8 Anti-hypertensive meds Y/N

12 heartrte Num 8 Ventricular Rate (beats/min)

13 glucose Num 8 Casual Glucose mg/dL

14 prevchd Num 8 Prevalent CHD (MI,AP,CI)

15 prevap Num 8 Prevalent Angina

16 prevmi Num 8 Prevalent MI (Hosp,Silent)

17 prevstrk Num 8 Prevalent Stroke (Infarct,Hem)

18 prevhyp Num 8 Prevalent Hypertension

19 time Num 8 Days since Index Exam

20 period Num 8 Examination cycle

21 hdlc Num 8 HDL Cholesterol mg/dL

22 ldlc Num 8 LDL Cholesterol mg/dL

23 death Num 8 Death indicator

24 angina Num 8 Incident Angina Pectoris

25 hospmi Num 8 Incident Hospitalized MI

26 mi_fchd Num 8 Incident Hosp MI-Fatal CHD

27 anychd Num 8 Incident Hosp MI, AP, CI, Fatal CHD

28 stroke Num 8 Incident Stroke Fatal/non-fatal

29 cvd Num 8 Incident Hosp MI or Stroke, Fatal or Non

30 hyperten Num 8 Incident Hypertension

31 timeap Num 8 Days Baseline-Inc Angina

32 timemi Num 8 Days Baseline-Inc Hosp MI

33 timemifc Num 8 Days Baseline-Inc MI-Fatal CHD

34 timechd Num 8 Days Baseline-Inc Any CHD

35 timestrk Num 8 Days Baseline-Inc Stroke

36 timecvd Num 8 Days Baseline-Inc CVD

37 timedth Num 8 Days Baseline-Death

38 timehyp Num 8 Days Baseline-Inc Hypertension

_________________________________________________________________________________________________

Distributions of selected variables by period and sex

Examination cycle 1

Means selected Risk factors N NMiss Mean Std Min P25 Median P75 Max

Men

Days since Index Exam 1944 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00

Age (years) at examination 1944 0 49.79 8.72 33.00 42.00 49.00 57.00 69.00

Body Mass Index (kg/(M*M) 1939 5 26.17 3.41 15.54 23.97 26.08 28.32 40.38

Systolic BP mmHg 1944 0 131.74 19.44 83.50 118.00 129.00 141.50 235.00

Diastolic BP mmHg 1944 0 83.71 11.44 48.00 76.00 82.00 90.00 136.00

Serum Cholesterol mg/dL 1937 7 233.58 42.36 113.00 206.00 231.00 259.00 696.00

HDL Cholesterol mg/dL 0 1944 . . . . . . .

LDL Cholesterol mg/dL 0 1944 . . . . . . .

Casual Glucose mg/dL 1824 120 82.32 24.72 40.00 71.00 78.00 87.00 394.00

Cigarettes per day 1928 16 13.23 13.78 0.00 0.00 10.50 20.00 70.00

Ventricular Rate (beats/min) 1943 1 74.40 11.90 44.00 66.00 75.00 80.00 130.00

Women

Days since Index Exam 2490 0 0.00 0.00 0.00 0.00 0.00 0.00 0.00

Age (years) at examination 2490 0 50.03 8.64 32.00 43.00 49.00 57.00 70.00

Body Mass Index (kg/(M*M) 2476 14 25.59 4.56 15.96 22.54 24.83 27.82 56.80

Systolic BP mmHg 2490 0 133.82 24.46 83.50 116.00 128.50 146.50 295.00

Diastolic BP mmHg 2490 0 82.60 12.50 50.00 74.00 81.00 89.00 142.50

Serum Cholesterol mg/dL 2445 45 239.68 46.22 107.00 206.00 237.00 269.00 600.00

HDL Cholesterol mg/dL 0 2490 . . . . . . .

LDL Cholesterol mg/dL 0 2490 . . . . . . .

Casual Glucose mg/dL 2213 277 82.07 24.14 40.00 72.00 78.00 86.00 394.00

Cigarettes per day 2474 16 5.65 8.96 0.00 0.00 0.00 10.00 50.00

Ventricular Rate (beats/min) 2490 0 77.06 12.15 46.00 69.00 75.00 85.00 143.00

Examination cycle 2

Men

Days since Index Exam 1691 0 2173.67 72.44 1577.00 2142.00 2174.00 2205.00 2520.00

Age (years) at examination 1691 0 55.10 8.51 39.00 48.00 54.00 62.00 75.00

Body Mass Index (kg/(M*M) 1685 6 26.23 3.40 16.24 24.05 26.09 28.23 39.46

Systolic BP mmHg 1691 0 135.48 19.90 88.00 120.00 132.00 148.00 216.00

Diastolic BP mmHg 1691 0 84.61 10.91 53.00 78.00 84.00 91.00 124.00

Serum Cholesterol mg/dL 1666 25 241.82 42.14 115.00 214.00 240.00 266.00 614.00

HDL Cholesterol mg/dL 0 1691 . . . . . . .

LDL Cholesterol mg/dL 0 1691 . . . . . . .

Casual Glucose mg/dL 1518 173 82.24 23.31 40.00 70.00 77.00 88.00 362.00

Cigarettes per day 1682 9 12.23 15.04 0.00 0.00 2.00 20.00 90.00

Ventricular Rate (beats/min) 1691 0 75.92 12.66 42.00 68.00 75.00 83.00 130.00

Women

Days since Index Exam 2239 0 2176.22 76.20 1633.00 2144.00 2175.00 2207.00 2765.00

Age (years) at examination 2239 0 55.66 8.56 39.00 48.00 55.00 62.00 76.00

Body Mass Index (kg/(M*M) 2229 10 25.65 4.58 15.33 22.54 24.88 27.85 56.80

Systolic BP mmHg 2239 0 138.06 24.30 88.00 121.00 134.00 151.00 282.00

Diastolic BP mmHg 2239 0 83.57 11.79 47.00 76.00 82.00 90.00 150.00

Serum Cholesterol mg/dL 2121 118 255.67 47.53 122.00 223.00 252.00 285.00 638.00

HDL Cholesterol mg/dL 0 2239 . . . . . . .

LDL Cholesterol mg/dL 0 2239 . . . . . . .

Casual Glucose mg/dL 1931 308 81.76 21.32 39.00 71.00 78.00 87.00 420.00

Cigarettes per day 2215 24 5.97 10.00 0.00 0.00 0.00 10.00 60.00

Ventricular Rate (beats/min) 2238 1 78.36 12.76 45.00 70.00 75.00 85.00 220.00

_________________________________________________________________________________________________

Means selected Risk factors N NMiss Mean Std Min P25 Median P75 Max

Examination cycle 3

Men

Days since Index Exam 1387 0 4353.75 97.74 3748.00 4312.00 4361.00 4403.00 4816.00

Age (years) at examination 1387 0 60.35 8.19 45.00 53.00 60.00 67.00 80.00

Body Mass Index (kg/(M*M) 1380 7 26.22 3.49 14.43 24.02 26.09 28.25 45.43

Systolic BP mmHg 1387 0 139.26 21.15 91.00 123.00 136.00 152.00 225.00

Diastolic BP mmHg 1387 0 82.55 11.29 30.00 75.00 81.50 90.00 123.00

Serum Cholesterol mg/dL 1312 75 225.74 41.13 130.00 198.00 222.00 252.00 413.00

HDL Cholesterol mg/dL 1304 83 43.71 13.30 10.00 35.00 42.00 51.00 138.00

LDL Cholesterol mg/dL 1304 83 170.55 44.66 34.00 140.00 167.50 199.00 376.00

Casual Glucose mg/dL 1163 224 91.17 28.99 49.00 77.00 85.00 97.00 423.00

Cigarettes per day 1380 7 8.70 13.51 0.00 0.00 0.00 20.00 80.00

Ventricular Rate (beats/min) 1387 0 75.88 12.73 43.00 66.00 75.00 85.00 150.00

Women

Days since Index Exam 1876 0 4353.61 93.13 3919.00 4313.00 4362.00 4402.50 4854.00

Age (years) at examination 1876 0 60.87 8.37 44.00 54.00 60.00 67.00 81.00

Body Mass Index (kg/(M*M) 1866 10 25.65 4.45 14.53 22.59 24.80 27.94 56.80

Systolic BP mmHg 1876 0 140.92 24.14 86.00 123.00 138.00 156.00 267.00

Diastolic BP mmHg 1876 0 81.23 11.23 46.00 73.00 80.00 88.00 130.00

Serum Cholesterol mg/dL 1737 139 245.00 45.08 112.00 214.00 242.00 270.00 625.00

HDL Cholesterol mg/dL 1723 153 53.64 15.90 11.00 43.00 52.00 62.00 189.00

LDL Cholesterol mg/dL 1722 154 180.95 48.00 20.00 149.00 177.00 208.00 565.00

Casual Glucose mg/dL 1538 338 88.72 27.48 46.00 76.00 84.00 95.00 478.00

Cigarettes per day 1869 7 5.35 9.78 0.00 0.00 0.00 8.00 60.00

Ventricular Rate (beats/min) 1872 4 78.45 12.20 37.00 70.00 77.00 85.00 130.00

_______________________________________________________________________________________________________________________________________

Examination cycle

1 2 3

______________________________________________________________________________________________________________________________________

Men Women Men Women Men Women

_____________________________________________________________________________________________________________________________________

N Percent N Percent N Percent N Percent N Percent N Percent

Total 1944 100.00 2490 100.00 1691 100.00 2239 100.00 1387 100.00 1876 100.00

Current Cig Smoker Y/N

No 769 39.56 1484 59.60 811 47.96 1392 62.17 848 61.14 1294 68.98

Yes 1175 60.44 1006 40.40 880 52.04 847 37.83 539 38.86 582 31.02

Diabetic Y/N

No 1885 96.97 2428 97.51 1617 95.62 2158 96.38 1267 91.35 1742 92.86

Yes 59 3.03 62 2.49 74 4.38 81 3.62 120 8.65 134 7.14

Anti-hypertensive meds Y/N

Missing 22 1.13 39 1.57 37 2.19 49 2.19 189 13.63 257 13.70

No 1880 96.71 2349 94.34 1553 91.84 1920 85.75 1060 76.42 1328 70.79

Yes 42 2.16 102 4.10 101 5.97 270 12.06 138 9.95 291 15.51

Prevalent CHD (MI,AP,CI)

No 1820 93.62 2420 97.19 1516 89.65 2126 94.95 1187 85.58 1716 91.47

Yes 124 6.38 70 2.81 175 10.35 113 5.05 200 14.42 160 8.53

Prevalent MI (Hosp,Silent)

No 1874 96.40 2474 99.36 1588 93.91 2212 98.79 1272 91.71 1833 97.71

Yes 70 3.60 16 0.64 103 6.09 27 1.21 115 8.29 43 2.29

Prevalent Angina

No 1852 95.27 2435 97.79 1564 92.49 2146 95.85 1254 90.41 1749 93.23

Yes 92 4.73 55 2.21 127 7.51 93 4.15 133 9.59 127 6.77

Prevalent Stroke (Infarct,Hem)

No 1930 99.28 2472 99.28 1675 99.05 2204 98.44 1357 97.84 1837 97.92

Yes 14 0.72 18 0.72 16 0.95 35 1.56 30 2.16 39 2.08

Prevalent Hypertension

No 1313 67.54 1691 67.91 841 49.73 1130 50.47 542 39.08 766 40.83

Yes 631 32.46 799 32.09 850 50.27 1109 49.53 845 60.92 1110 59.17

____________________________________________________________________________________________

Event Counts by sex

Counts of Endpoints by Sex SEX

_____________________________________________

Men Women

_____________________________________________

N Percent N Percent

All 1944 100.00 2490 100.00

Incident Hypertension

No 540 27.78 642 25.78

Yes 1404 72.22 1848 74.22

Incident Angina Pectoris

No 1561 80.30 2148 86.27

Yes 383 19.70 342 13.73

Incident Hospitalized MI

No 1624 83.54 2356 94.62

Yes 320 16.46 134 5.38

Incident Hosp MI-Fatal CHD

No 1453 74.74 2250 90.36

Yes 491 25.26 240 9.64

Incident Stroke Fatal/non-fatal

No 1751 90.07 2268 91.08

Yes 193 9.93 222 8.92

Incident Hosp MI, AP, CI, Fatal CHD

No 1234 63.48 1960 78.71

Yes 710 36.52 530 21.29

Incident Hosp MI or Stroke, Fatal or Non

No 1258 64.71 2019 81.08

Yes 686 35.29 471 18.92

Death indicator

No 1101 56.64 1783 71.61

Yes 843 43.36 707 28.39

______________________________________________________________________________________________________________________________________

Distributions of Time to Event by sex

Time to Event N NMiss Mean Std Min P25 Median P75 Max

Men Days Baseline-Inc Hypertension 1944 0 3313 3391 0 0 2156 6491 8766

Days Baseline-Inc Angina 1944 0 6507 2929 0 4572 8486 8766 8766

Days Baseline-Inc Hosp MI 1944 0 6736 2771 0 5006 8766 8766 8766

Days Baseline-Inc MI-Fatal CHD 1944 0 6655 2816 0 4822 8743 8766 8766

Days Baseline-Inc Stroke 1944 0 7003 2509 0 5608 8766 8766 8766

Days Baseline-Inc Any CHD 1944 0 6156 3067 0 3853 7653 8766 8766

Days Baseline-Inc CVD 1944 0 6274 3015 0 4009 7895 8766 8766

Days Baseline-Death 1944 0 7194 2386 26 6047 8766 8766 8766

Women Days Baseline-Inc Hypertension 2490 0 3532 3496 0 0 2219 7340 8766

Days Baseline-Inc Angina 2490 0 7209 2559 0 6132 8766 8766 8766

Days Baseline-Inc Hosp MI 2490 0 7634 2154 0 7541 8766 8766 8766

Days Baseline-Inc MI-Fatal CHD 2490 0 7600 2197 0 7452 8766 8766 8766

Days Baseline-Inc Stroke 2490 0 7540 2262 0 7283 8766 8766 8766

Days Baseline-Inc Any CHD 2490 0 7065 2656 0 5618 8766 8766 8766

Days Baseline-Inc CVD 2490 0 7243 2549 0 6241 8766 8766 8766

Days Baseline-Death 2490 0 7749 2037 34 8016 8766 8766 8766

Age Specific Angina and Hospitalized MI-Fatal CHD Incidence Rates by Sex

Angina Hospitalized MI - Fatal CHD

Person Rate/ Person Rate/

N* Years Events 1,000PY N* Years Events 1,000PY

Men

35-44 649 3,053 12 3.9 644 3,037 8 2.6

45-54 1,278 9,587 52 5.4 1,269 9,498 67 7.1

55-64 1,646 12,241 135 11.0 1,629 12,274 154 12.5

65-74 1,115 7,488 78 10.4 1,125 7,623 117 15.3

75-84 416 2,165 13 6.0 432 2,210 43 19.5

85+ 52 93 1 10.8 54 97 6 62.0

Women

35-44 783 3,765 3 0.8 783 3,769 2 0.5

45-54 1,634 12,316 26 2.1 1,631 12,400 12 1.0

55-64 2,229 17,261 123 7.1 2,238 17,675 60 3.4

65-74 1,640 11,679 98 8.4 1,705 12,421 78 6.3

75-84 707 3,815 35 9.2 769 4,262 55 12.9

85+ 106 287 2 7.0 121 316 7 22.1

N* - Number of persons contributing person years to that age group. Incidence rates are calculated

using derived age at time of event.

Age Specific Stroke and Cardiovascular Disease (Fatal and Non-Fatal) Incidence Rates by Sex

Stroke Cardiovascular Disease (CVD)

Person Rate/ Person Rate/

N* Years Events 1,000PY N* Years Events 1,000PY

Men

35-44 655 3,082 1 0.3 643 3,010 13 4.3

45-54 1,313 9,921 14 1.4 1,260 9,353 95 10.2

55-64 1,743 13,293 42 3.2 1,588 11,769 202 17.2

65-74 1,256 8,471 74 8.7 1,058 6,920 185 26.7

75-84 477 2,402 44 18.3 378 1,839 75 40.8

85+ 50 97 4 41.1 41 65 9 138.0

Women

35-44 782 3,761 2 0.5 781 3,759 5 1.3

45-54 1,638 12,420 10 0.8 1,621 12,282 31 2.5

55-64 2,283 17,932 47 2.6 2,209 17,180 133 7.7

65-74 1,760 12,713 83 6.5 1,631 11,588 148 12.8

75-84 774 4,230 52 12.3 695 3,737 85 22.7

85+ 124 322 10 31.0 103 264 15 56.8

N* - Number of persons contributing person years to that age group. Incidence rates are calculated

using derived age at time of event.

For CVD endpoint, population at risk defined by PREVCHD=0 AND PREVSTRK=0

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