Academic Success and Professional Development Plan Part 4: Research Analysis

Significantly improved neurocognitive function in major depressive disorders 6 weeks after ECT.

Authors:

Mohn C ; Research Department, Vestre Viken Hospital Trust, Drammen, Norway. Electronic address: h.c.mohn@psykologi.uio.no. Rund BR; Research Department, Vestre Viken Hospital Trust, Drammen, Norway; Department of Psychology, University of Oslo, Oslo, Norway.

Source:

Journal of affective disorders  [J Affect Disord] 2016 Sep 15; Vol. 202, pp. 10-5. Date of Electronic Publication: 2016 May 20.

Publication Type:

Journal Article

Language:

English

Journal Info:

Publisher:  Elsevier/North-Holland Biomedical Press  Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN:  01650327  NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE

Imprint Name(s):

Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press.

MeSH Terms:

Cognition* Cognition Disorders /*therapy Depressive Disorder, Major /*therapy Electroconvulsive Therapy/*methods Adult ; Attention ; Cognition Disorders /etiology ; Cognition Disorders /psychology ;  Depressive Disorder, Major /complications ;  Depressive Disorder, Major /psychology ; Female ; Follow-Up Studies ; Humans ; Male ; Memory ; Middle Aged ; Neuropsychological Tests ; Prospective Studies ; Treatment Outcome

Abstract:

Background: Cognitive side effects may occur after electroconvulsive treatment (ECT) in depressive disorder patients. Previous studies have been limited by small numbers of cognitive functions assessed. The present study reports the first results from a prospective project monitoring cognitive effects of ECT using a comprehensive neuropsychological test battery and subjective report of everyday cognitive function. Methods: Thirty-one patients with major depressive disorder were assessed with the MATRICS Consensus Cognitive Battery (MCCB). Subjective cognitive complaints were described with the Everyday Memory Questionnaire (EMQ). Severity of depression symptoms were assessed with the Montgomery-Åsberg Depression Rating Scale (MADRS). These assessments were performed prior to and 6 weeks after non-standardized ECT. Results: Compared to baseline, the mean depression severity level was nearly halved and there were significant improvements in mean levels of Speed of Processing, Attention/Vigilance, and Visual Learning 6 weeks after ECT. The other cognitive domains were not altered from baseline. There was no significant change in subjective cognitive complaints. At baseline, there were several significant correlations between the MADRS and MCCB scores. There was no strong association between the EMQ and MCCB scores at either assessment point, but the post-ECT EMQ score was significantly correlated with depression severity. Limitations: Major limitations were low N and lack of uniform ECT procedure. Conclusions: There was significant improvement in Speed of Processing, Attention/Vigilance, and Visual Learning 6 weeks after ECT. Cognitive tests scores were related to severity of depression, but not to subjective memory complaints. (Copyright © 2016 Elsevier B.V. All rights reserved.)

Contributed Indexing:

Keywords: Cognition*; Depression*; ECT*; MCCB*; Memory*; Neuropsychology*

Entry Date(s):

Date Created: 20160603 Date Completed: 20171128 Latest Revision: 20190318

Update Code:

20200827

DOI:

10.1016/j.jad.2016.03.062

PMID:

27253211

Database:

MEDLINE with Full Text